Treatment of Clostridium difficile-Associated Disease

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Presentation transcript:

Treatment of Clostridium difficile-Associated Disease Daniel A. Leffler, J. Thomas Lamont Gastroenterology Volume 136, Issue 6, Pages 1899-1912 (May 2009) DOI: 10.1053/j.gastro.2008.12.070 Copyright © 2009 AGA Institute Terms and Conditions

Figure 1 Pathogenesis of C difficile infection. Gastroenterology 2009 136, 1899-1912DOI: (10.1053/j.gastro.2008.12.070) Copyright © 2009 AGA Institute Terms and Conditions

Figure 2 Age-related prevalence of antibody to C difficile toxin A and B. Modified from Viscidi et al.6 Gastroenterology 2009 136, 1899-1912DOI: (10.1053/j.gastro.2008.12.070) Copyright © 2009 AGA Institute Terms and Conditions

Figure 3 Recent increase in reported treatment failures for metronidazole. Modified from Aslam et al.46 Gastroenterology 2009 136, 1899-1912DOI: (10.1053/j.gastro.2008.12.070) Copyright © 2009 AGA Institute Terms and Conditions

Figure 4 Equivalent response of low and high dose vancomycin. (Modified with permission from Fekety et al.42) Gastroenterology 2009 136, 1899-1912DOI: (10.1053/j.gastro.2008.12.070) Copyright © 2009 AGA Institute Terms and Conditions

Figure 5 Vancomycin is more effective than metronidazole for severe C difficile infection. Modified with permission from Zar et al.48 Gastroenterology 2009 136, 1899-1912DOI: (10.1053/j.gastro.2008.12.070) Copyright © 2009 AGA Institute Terms and Conditions

Daniel A. Leffler Gastroenterology 2009 136, 1899-1912DOI: (10.1053/j.gastro.2008.12.070) Copyright © 2009 AGA Institute Terms and Conditions

J. Thomas Lamont Gastroenterology 2009 136, 1899-1912DOI: (10.1053/j.gastro.2008.12.070) Copyright © 2009 AGA Institute Terms and Conditions