Counting Motors by Force

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Presentation transcript:

Counting Motors by Force Daniel St Johnston Cell Volume 135, Issue 6, Pages 1000-1001 (December 2008) DOI: 10.1016/j.cell.2008.11.021 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Stall Force Measurements Reveal the Number of Active Motors on Individual Lipid Droplets Lipid droplets undergo bidirectional movements along microtubules powered by kinesin-1 (blue) and dynein (orange) in the early Drosophila embryo (syncytium). Using a custom-built optical trap with an infrared laser (red), Shubeita et al. (2008) measured the forces required to stall the movement of lipid droplets along microtubules. This enabled them to count the number of active motors per droplet and to correlate this number with droplet dynamics. Cell 2008 135, 1000-1001DOI: (10.1016/j.cell.2008.11.021) Copyright © 2008 Elsevier Inc. Terms and Conditions