Feeling Stressed under the Sun? RPA1 Acetylation to the Rescue

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Presentation transcript:

Feeling Stressed under the Sun? RPA1 Acetylation to the Rescue Debabrata Chakravarti, Tapas K. Hazra Cell Reports Volume 20, Issue 9, Pages 1995-1996 (August 2017) DOI: 10.1016/j.celrep.2017.08.045 Copyright © 2017 The Author(s) Terms and Conditions

Figure 1 A Model Depicting Regulation of NER via RPA1 Acetylation NER is tightly regulated by RPA1 acetylation and deacetylation by PCAF and GCN5 acetyltransferases and HDAC6 and SIRT1 deacetylases, respectively. RPA acetylation enhances XPA1 retention on DNA lesions and promotes NER. For detail, see text and papers by He et al. (2017) and Zhao et al. (2017). For simplicity and to highlight RPA1-XPA interaction, all other NER proteins are noted as NER complex. Cell Reports 2017 20, 1995-1996DOI: (10.1016/j.celrep.2017.08.045) Copyright © 2017 The Author(s) Terms and Conditions