Volume 5, Issue 10, Pages (October 2018)

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Volume 5, Issue 10, Pages 816-823 (October 2018) The relationship between cortical glutamate and striatal dopamine in first-episode psychosis: a cross-sectional multimodal PET and magnetic resonance spectroscopy imaging study Sameer Jauhar, MRCPsych, Robert McCutcheon, MRCPsych, Faith Borgan, MSc, Mattia Veronese, PhD, Matthew Nour, MRCPsych, Fiona Pepper, MSc, M Rogdaki, MRCPsych, James Stone, PhD, Alice Egerton, PhD, Frederico Turkheimer, PhD, Prof Philip McGuire, FMedSci, Prof Oliver D Howes, PhD The Lancet Psychiatry Volume 5, Issue 10, Pages 816-823 (October 2018) DOI: 10.1016/S2215-0366(18)30268-2 Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 1 Voxel placement for measurement of anterior cingulate cortex glutamate concentrations The Lancet Psychiatry 2018 5, 816-823DOI: (10.1016/S2215-0366(18)30268-2) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 2 Relationship between anterior cingulate cortex glutamate concentrations and striatal dopamine synthesis capacity *p=0·39. †p=0·03. The Lancet Psychiatry 2018 5, 816-823DOI: (10.1016/S2215-0366(18)30268-2) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 3 Relationships between positive psychotic symptoms and (A) striatal dopamine synthesis capacity*, and (B) anterior cingulate cortex glutamate concentrations† The red line represents a linear regression where symptom scores are the dependent variable and the imaging measure is the independent variable.*p=0·046. †p=0·03. The Lancet Psychiatry 2018 5, 816-823DOI: (10.1016/S2215-0366(18)30268-2) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions