M. S. Laasanen, Ph. D. , J. Töyräs, Ph. D. , A. Vasara, M. D. , S

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Presentation transcript:

Quantitative ultrasound imaging of spontaneous repair of porcine cartilage M.S. Laasanen, Ph.D., J. Töyräs, Ph.D., A. Vasara, M.D., S. Saarakkala, M.Sc., M.M. Hyttinen, M.D., I. Kiviranta, M.D., Ph.D., Professor J.S. Jurvelin, Ph.D. Osteoarthritis and Cartilage Volume 14, Issue 3, Pages 258-263 (March 2006) DOI: 10.1016/j.joca.2005.09.011 Copyright © 2005 Terms and Conditions

Fig. 1 (A) After 3 months follow-up, the lesion site was found to be spontaneously filled by visually cartilage-like soft tissue showing smooth surface. Ultrasonic images (left) and corresponding toluidine blue stained microscopic section of the (B) control cartilage, (C) lesion immediately after creation (pilot sample) and (D) lesion site after 3 months follow-up. At the lesion site, ultrasonic images revealed degenerative changes in the subchondral bone in situ. The quantitative ultrasound analyses were conducted from the surfaces perpendicular to the scanning axis. Osteoarthritis and Cartilage 2006 14, 258-263DOI: (10.1016/j.joca.2005.09.011) Copyright © 2005 Terms and Conditions

Fig. 2 (A) It was seen that tissue thickness was highest at the lesion site. (B) Ultrasound reflection (R) was significantly lower at the lesion site than at the control cartilage. (C) Reflection from the cartilage–bone interface was lowest at the lesion site. (D) Cartilage surface roughness (URI) was significantly higher at the defect site as compared to control cartilage. Osteoarthritis and Cartilage 2006 14, 258-263DOI: (10.1016/j.joca.2005.09.011) Copyright © 2005 Terms and Conditions

Fig. 3 Typical microtopography at the surface of (A) control cartilage, (B) adjacent cartilage and (C) lesion site as detected with ultrasound. (D) URI correlated significantly with R. At the lesion site, URI was more sensitive to differences than R. However, R was a more sensitive indicator of variations at the adjacent cartilage and control site. Osteoarthritis and Cartilage 2006 14, 258-263DOI: (10.1016/j.joca.2005.09.011) Copyright © 2005 Terms and Conditions