Volume 373, Issue 9666, Pages (March 2009)

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Presentation transcript:

Volume 373, Issue 9666, Pages 821-828 (March 2009) Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial Prof Phil Quirke, FRCPath, Prof Robert Steele, MD, Prof John Monson, MD, Robert Grieve, FRCR, Subhash Khanna, FRCR, Jean Couture, MD, Chris O'Callaghan, PhD, Arthur Sun Myint, FRCR, Eric Bessell, FRCR, Lindsay C Thompson, MSc, Prof Mahesh Parmar, DPhil, Richard J Stephens, David Sebag-Montefiore, FRCR The Lancet Volume 373, Issue 9666, Pages 821-828 (March 2009) DOI: 10.1016/S0140-6736(09)60485-2 Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 1 Circumferential resection margin positivity rate during trial recruitment The Lancet 2009 373, 821-828DOI: (10.1016/S0140-6736(09)60485-2) Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 2 Effect of treatment on circumferential resection margin and plane of surgery subgroups CRM=circumferential resection margin. HR=hazard ratio. +ve=positive. −ve=negative. The Lancet 2009 373, 821-828DOI: (10.1016/S0140-6736(09)60485-2) Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 3 Plane of surgery achieved during trial recruitment The Lancet 2009 373, 821-828DOI: (10.1016/S0140-6736(09)60485-2) Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 4 Local recurrence rate (A) and disease-free survival (B) by plane of surgery achieved The Lancet 2009 373, 821-828DOI: (10.1016/S0140-6736(09)60485-2) Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 5 Effect of circumferential resection margin on local recurrence and disease-free survival in different planes of surgery achieved The Lancet 2009 373, 821-828DOI: (10.1016/S0140-6736(09)60485-2) Copyright © 2009 Elsevier Ltd Terms and Conditions