Mammalian Circadian Cogwheels Are Parts of Macromolecular Machines

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Mammalian Circadian Cogwheels Are Parts of Macromolecular Machines Ueli Schibler Molecular Cell Volume 67, Issue 5, Pages 727-729 (September 2017) DOI: 10.1016/j.molcel.2017.08.024 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Circadian Regulation of CLOCK:BMAL1 Activity At Zeitgeber Time 6 (ZT06), the 0.7 MDa complex containing CLOCK (C) and BMAL1 (B) is fully active. During the early repression phase (ZT12), a fraction of chromatin-bound C and B assemble into the 1.9 MDa PER:CRY complex. The levels of this complex increase, and CK1δ phosphorylates a few of its subunits (primarily PERs and CLOCK) in a temperature-compensated manner. This leads to the quantitative removal of C and B from chromatin at ZT18. At ZT00/24 a large fraction of the 1.9 MDa complex is degraded, and the C:B complex starts a new activity cycle (PER3, the third PER isoform, is also part of the 1.9 MDa complex, but its depletion has no functional consequences). Molecular Cell 2017 67, 727-729DOI: (10.1016/j.molcel.2017.08.024) Copyright © 2017 Elsevier Inc. Terms and Conditions