Volume 73, Issue 5, Pages (March 2008)

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Volume 73, Issue 5, Pages 622-629 (March 2008) CD14++CD16+ monocytes but not total monocyte numbers predict cardiovascular events in dialysis patients G.H. Heine, C. Ulrich, E. Seibert, S. Seiler, J. Marell, B. Reichart, M. Krause, A. Schlitt, H. Köhler, M. Girndt Kidney International Volume 73, Issue 5, Pages 622-629 (March 2008) DOI: 10.1038/sj.ki.5002744 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 Monocyte subsets: CD86+ cells with monocyte scatter properties were gated and monocyte subpopulations were defined according to their surface expression pattern of the LPS receptor CD14 and the Fcγ receptor CD16 (representative example of a hemodialysis patient (74 years of age, male, no prevalent cardiovascular disease at study entry) and an age- and gender-matched healthy control subject (73 years of age, male, no prevalent cardiovascular disease)). Kidney International 2008 73, 622-629DOI: (10.1038/sj.ki.5002744) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 2 Survival without cardiovascular events of the cohort by quartiles of total and differential leukocyte counts. Kaplan–Meier analysis with log-rank test. Kidney International 2008 73, 622-629DOI: (10.1038/sj.ki.5002744) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 3 Survival without cardiovascular events of the cohort by quartiles of differential monocyte counts. Kaplan–Meier analysis with log-rank test. Kidney International 2008 73, 622-629DOI: (10.1038/sj.ki.5002744) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 4 Percentage of patients suffering cardiovascular events and/or death across tertiles of CD14++CD16+ monocyte counts (Mo 1–3=first to third tertiles) and C-reactive protein (CRP 1–3=first to third tertiles). Graded increases in the risk of cardiovascular events and/or death are found across increasing tertiles of CD14++CD16+ monocyte counts for any tertile of CRP levels. Kidney International 2008 73, 622-629DOI: (10.1038/sj.ki.5002744) Copyright © 2008 International Society of Nephrology Terms and Conditions