Volume 72, Issue 2, Pages (July 2007)

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Volume 72, Issue 2, Pages 145-150 (July 2007) The endothelium-derived hyperpolarizing factor: insights from genetic animal models R. Köhler, J. Hoyer Kidney International Volume 72, Issue 2, Pages 145-150 (July 2007) DOI: 10.1038/sj.ki.5002303 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Putative EDHF signalling pathways related to endothelial and smooth muscle ion-channel opening (upper panel). Impaired endothelial and smooth muscle hyperpolarization in IKCa/KCa3.1 KO mice leads to defective EDHF-mediated vasodilation and elevated systemic blood pressure (lower panel). AA, arachidonic acid; ACh, acetylcholine; BKCa, large-conductance Ca2+-activated K+ channel (KCa1.1); CYP, cytochrome P450 epoxygenase; EET, epoxyeicosatrienoic acid; ER, endoplasmic reticulum; GPCR, G-protein coupled receptor; IKCa, intermediate-conductance Ca2+-activated K+ channel (KCa3.1); Kir, inwardly-rectifying K+ channel; SKCa, small-conductance Ca2+-activated K+ channel (KCa2.3); VDCC, voltage-dependent Ca2+ channel. Kidney International 2007 72, 145-150DOI: (10.1038/sj.ki.5002303) Copyright © 2007 International Society of Nephrology Terms and Conditions