Nitric oxide mediates neurologic injury after hypothermic circulatory arrest Elaine E Tseng, MD, Malcolm V Brock, MD, Mary S Lange, MA, Juan C Troncoso,

Slides:

Advertisements

Similar presentations

Myocardial functional recovery after fibroblast growth factor 2 gene therapy as assessed by echocardiography and magnetic resonance imaging Keith A Horvath,

Advertisements

The N-methyl-D -aspartate antagonist memantine has no neuroprotective effect during hypothermic circulatory arrest: A study in the chronic porcine model

Ph-stat versus alpha-stat perfusion strategy during experimental hypothermic circulatory arrest: a microdialysis study Matti Pokela, MD, Sebastian Dahlbacka,

Topical head cooling during rewarming after experimental hypothermic circulatory arrest Matti Pokela, MD, Janne Heikkinen, MS, Fausto Biancari, MD, PhD,

Serum levels of neuron-specific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest George.

Inhaled nitric oxide reduces human lung allograft dysfunction

Glutamate excitotoxicity: A mechanism of neurologic injury associated with hypothermic circulatory arrest J.M. Redmond, FRCSI (by invitation), A.M. Gillinov,

Mary E. Huerter, MD, MA, Ashish K

Elaine E. Tseng, MD, Malcolm V. Brock, MD, Mary S. Lange, MA, Juan C

Time course and cellular localization of inducible nitric oxide synthases expression during cardiac allograft rejection Neil K Worrall, MD, Thomas P.

Serum levels of neuron-specific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest George.

Thomas V Bilfinger, MD, George B Stefano, PhD

Serum S100B and hypothermic circulatory arrest in adults

Assessing the impact of cerebral injury after cardiac surgery: will determining the mechanism reduce this injury? William A Baumgartner, MD, Peter L.

Cerebral metabolic recovery from deep hypothermic circulatory arrest after treatment with arginine and nitro-arginine methyl ester Takeshi Hiramatsu,

CTSNet: a unique educational vehicle

Erythropoietin protects the central nervous system during prolonged hypothermic circulatory arrest: An experimental study in a canine model Mitsuhiro.

Bashir M Matata, PhD, Andrzej W Sosnowski, MD, Manuel Galiñanes

Differential neuronal vulnerability varies according to specific cardiopulmonary bypass insult in a porcine survival model Nobuyuki Ishibashi, MD, Yusuke.

Hyperoxia for management of acid-base status during deep hypothermia with circulatory arrest Jeffrey M Pearl, MD, Donald W Thomas, Gary Grist, Jodie.

Brian T Feeley, BS, Aric K Park, BS, Sophoclis Alexopoulos, BS, E

Susanne Lison, MD, Michael Spannagl, MD, PhD, Wulf Dietrich, MD, PhD

Nanotechnology Approaches to Targeting Inflammation and Excitotoxicity in a Canine Model of Hypothermic Circulatory Arrest–Induced Brain Injury Joshua.

Increased intracerebral excitatory amino acids and nitric oxide after hypothermic circulatory arrest Elaine E Tseng, MD, Malcolm V Brock, MD, Christopher.

Neuronal Cell Death in the Ischemic Spinal Cord: The Effect of Methylprednisolone Georgios K. Kanellopoulos, MD, Hiroyuki Kato, MD, PhD, Yingji Wu, MSc,

Neuronal Nitric Oxide Synthase Inhibition Reduces Neuronal Apoptosis After Hypothermic Circulatory Arrest Elaine E Tseng, Malcolm V Brock, Mary S Lange,

Sam Chitsaz, MD, Nicolas Jaussaud, MD, Edward Chau, MD, Kimberly S

Topical head cooling during rewarming after experimental hypothermic circulatory arrest Matti Pokela, MD, Janne Heikkinen, MS, Fausto Biancari, MD, PhD,

Deep hypothermic circulatory arrest: II

Metabolic correlates of neurologic and behavioral injury after prolonged hypothermic circulatory arrest Craig K. Mezrow, MSa, Alejandro Gandsas, MDa,

Modification of Infarct Material Properties Limits Adverse Ventricular Remodeling Masato Morita, MD, Chad E. Eckert, PhD, Kanji Matsuzaki, MD, PhD, Mio.

Improved Cerebral Recovery From Hypothermic Circulatory Arrest After Remote Ischemic Preconditioning Fredrik S. Yannopoulos, MB, Tuomas Mäkelä, MB, Eija.

Coronary surgery without cardiotomy suction and autotransfusion reduces the postoperative systemic inflammatory response Martin Westerberg, MD, Anders.

Effect of profound hypothermia during circulatory arrest on neurologic injury and apoptotic repressor protein Bcl-2 expression in an acute porcine model

Masahiro Ono, MD, PhD, Charles Brown, MD, Jennifer K

Kazunori Yoshida, MD, Satoshi Tobe, MD, Masahito Kawata, MD

Effects of perfusion mode on regional and global organ blood flow in a neonatal piglet model Akif Ündar, PhD, Takafumi Masai, MD, Shuang-Qiang Yang,

Blood gas management and degree of cooling: Effects on cerebral metabolism before and after circulatory arrest Lynne A. Skaryak, MDa, Paul J. Chai, MDa,

Laki J. Rousou, MS, MD, Kristin B

Noninvasive Assessment of Brain Injury in a Canine Model of Hypothermic Circulatory Arrest Using Magnetic Resonance Spectroscopy Christopher J. Barreiro,

Andreas Zierer, MD, Marc R. Moon, MD, Spencer J

Editorial Board, January 2010

Sarah C. Huen, MD, Chirag R. Parikh, MD, PhD

Hypothermic Low-Flow Cardiopulmonary Bypass Impairs Pulmonary and Right Ventricular Function More Than Circulatory Arrest Jess M. Schultz, MD, Tara Karamlou,

C.Thomas Wass, David G Cable, Hartzell V Schaff, William L Lanier

Combination of alpha-stat strategy and hemodilution exacerbates neurologic injury in a survival piglet model with deep hypothermic circulatory arrest

Histopathologic consequences of hyperglycemic cerebral ischemia during hypothermic cardiopulmonary bypass in pigs Brendan P Conroy, MD, Marjorie R Grafe,

Myocardial functional recovery after fibroblast growth factor 2 gene therapy as assessed by echocardiography and magnetic resonance imaging Keith A Horvath,

Cardiac surgery with deep hypothermic circulatory arrest produces less systemic inflammatory response than low-flow cardiopulmonary bypass in newborns

Jorge D. Salazar, MD, Ryan D

Sequential Design for Clinical Trials Evaluating a Prosthetic Heart Valve Cody Hamilton, PhD, Michael Lu, PhD, Steven Lewis, PhD, William Anderson, PhD

Combined l-arginine and antioxidative vitamin treatment mollifies ischemia-reperfusion injury of skeletal muscle Joseph Nanobashvili, MD, Christoph Neumayer,

Adenosine-enhanced ischemic preconditioning provides myocardial protection equal to that of cold blood cardioplegia James D McCully, PhD, Masahisa Uematsu,

Involvement of apoptosis in neurological injury after hypothermic circulatory arrest: a new target for therapeutic intervention? Christian Hagl, MD,

Postischemic Function and Protein Kinase C Signal Transduction

Quantitative electroencephalography: A method to assess cerebral injury after hypothermic circulatory arrest Craig K. Mezrow, MSa (by invitation), Peter.

Effect of Nitric Oxide Gas on Platelets During Open Heart Operations

Randomized Controlled Trial of Pericardial Blood Processing With a Cell-Saving Device on Neurologic Markers in Elderly Patients Undergoing Coronary Artery.

The American Board of Thoracic Surgery: Update

Neal S Goldstein, MD The Annals of Thoracic Surgery

“Transitions” for Cardiothoracic Surgeons Now Listed on the Web:

Aprotinin in deep hypothermic circulatory arrest

Prospective randomized neurocognitive and S-100 study of hypothermic circulatory arrest, retrograde brain perfusion, and antegrade brain perfusion for.

Platelet-activating factor receptor antagonism improves cerebral recovery after circulatory arrest Stephen M Langley, Paul J Chai, MD, James J Jaggers,

The Brain Uses Mostly Dissolved Oxygen During Profoundly Hypothermic Cardiopulmonary Bypass Franklin Dexter, MD, PhD, Frank H Kern, MD, Bradley J Hindman,

Mechanisms responsible for cell volume regulation during hyperkalemic cardioplegic arrest Xiwu Sun, MD, PhD, Christopher T Ducko, MD, Eric M Hoenicke,

Randy M. Stevens, MD, M. Salik Jahania, MD, Robert M

Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites Randy M Stevens, MD, M.Salik Jahania, MD, Jennifer E.

A prospective randomized study of neurocognitive function and S-100 protein after antegrade or retrograde brain perfusion with hypothermic arrest for.

A randomized trial of antithrombin concentrate for treatment of heparin resistance Mathew R Williams, MD, Alyssa B D’Ambra, BA, James R Beck, Talia B.

Presentation transcript:

Nitric oxide mediates neurologic injury after hypothermic circulatory arrest Elaine E Tseng, MD, Malcolm V Brock, MD, Mary S Lange, MA, Juan C Troncoso, MD, Charles J Lowenstein, MD, Mary E Blue, PhD, Michael V Johnston, MD, William A Baumgartner, MD The Annals of Thoracic Surgery Volume 67, Issue 1, Pages 65-71 (January 1999) DOI: 10.1016/S0003-4975(98)01363-0

Fig 1 In vivo measurement of NOS activity as citrulline concentration (μmol/L) over time. Peak levels of citrulline were plotted over three time periods: HCA, reperfusion CPB 2 to 8 hours after HCA. (∗ = p < 0.05, 2 to 8 hours versus baseline. ∗∗ = p < 0.05, 17477AR versus untreated HCA control [Ctl] group.) The Annals of Thoracic Surgery 1999 67, 65-71DOI: (10.1016/S0003-4975(98)01363-0)

Fig 2 Nitric oxide synthase (NOS) activity (pmol 14C-citrulline · mg protein−1 · min−1) in the dorsolateral neocortex in untreated control dogs, HCA dogs at 72 hours, and 17477AR-treated dogs at 72 hours after HCA.∗p < 0.05 compared with untreated HCA dogs. The Annals of Thoracic Surgery 1999 67, 65-71DOI: (10.1016/S0003-4975(98)01363-0)

Fig 3 Tympanic membrane temperatures (°C) during cooling CPB, HCA, rewarming CPB, and recovery. The Annals of Thoracic Surgery 1999 67, 65-71DOI: (10.1016/S0003-4975(98)01363-0)

Fig 4 Neurologic deficit score of HCA dogs versus 17477AR-treated dogs over time. (∗ = p < 0.05, 17477AR versus HCA alone.) The Annals of Thoracic Surgery 1999 67, 65-71DOI: (10.1016/S0003-4975(98)01363-0)

Fig 5 Treatment with 17477AR reduced necrosis 72 hours after HCA, as seen by hemotoxylin and eosin–stained sections of the CA1 region of the hippocampus (40× magnification): (A) normal untreated control dog; (B) HCA dog at 72 hours (arrows indicate necrosis); (C) dog treated with 17477AR after HCA. The Annals of Thoracic Surgery 1999 67, 65-71DOI: (10.1016/S0003-4975(98)01363-0)