S.G. John, N.M. Selby, C.W. McIntyre Kidney International

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Presentation transcript:

Effects of peritoneal dialysis fluid biocompatibility on baroreflex sensitivity S.G. John, N.M. Selby, C.W. McIntyre Kidney International Volume 73, Pages S119-S124 (April 2008) DOI: 10.1038/sj.ki.5002612 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 Systolic and diastolic blood pressure. Systolic blood pressure was significantly higher in both fluids, in conventional fluid during 1.36/3.86% exchange, in biocompatible fluid during 3.86% dwell. Kidney International 2008 73, S119-S124DOI: (10.1038/sj.ki.5002612) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 2 Systemic hemodynamics. Total peripheral resistance (TPR) increased with both fluids. Stroke volume (SV) in biocompatible fluid was significantly lower and biocompatible fluid TPR was significantly higher than conventional fluid during the majority of the study. All data are presented as percentage change from baseline. Kidney International 2008 73, S119-S124DOI: (10.1038/sj.ki.5002612) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 3 Baroreflex sensitivity. BRS was more variable with conventional fluid. Conventional fluid demonstrated higher BRS than biocompatible fluid during both 1.36% and 3.86% dwell. BRS fell during 3.86% dwell by ∼30%. Kidney International 2008 73, S119-S124DOI: (10.1038/sj.ki.5002612) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 4 Plasma glucose and insulin. Fluid biocompatibility did not affect either parameter. Higher glucose concentration PD fluid was associated with hyperinsulinemia and hyperglycemia. Kidney International 2008 73, S119-S124DOI: (10.1038/sj.ki.5002612) Copyright © 2008 International Society of Nephrology Terms and Conditions