Figure 2 Sources of data to characterize the ADPKD clinical phenotype

Slides:



Advertisements
Similar presentations
Clinical Section: Added Value of a Paper (Novelty, quality, solidity, timely, etc …) Number of patients (families): ranges from > 1 to N … Natural history.
Advertisements

Definitions and classification of office blood pressure levels (mmHg) Modified by ESC Guidelines 2013 CARDIOcheckAPP.
Dr Godfrey Grech University of Malta
Cancers of the Digestive System November 19, 2007 NCDD Meeting Chair: John M. Carethers, MD Vice Chair: Robert Sandler, MD, MPH.
European Patients’ Academy on Therapeutic Innovation Challenges in Personalised Medicine.
Status Epilepticus Presenting After Traumatic Brain Injury in Infants Kurz, J. E.1; Zelleke, T.1; Carpenter, J.1; Dean, N.2; Singh, J.1; Kadom, N.3; Gaillard,
Nat. Rev. Neurol. doi: /nrneurol
Nat. Rev. Nephrol. doi: /nrneph
Figure 5 A layered approach to the follow-up of patients with acute kidney disease (AKD) Figure 5 | A layered approach to the follow-up of patients with.
Figure 2 The US Centers for Disease Control and
Figure 4 Time course of the development of physiological changes
Figure 6 Effects of adiponectin on podocyte function
Figure 4 The theoretical contribution of genetic and
Figure 3 Energy metabolism regulation, cardiovascular and bone disease in CKD Figure 3 | Energy metabolism regulation, cardiovascular and bone disease.
Figure 6 Approach to drug management in patients with acute kidney disease (AKD) Figure 6 | Approach to drug management in patients with acute kidney disease.
Figure 3 Angiotensin signalling in adiporenal crosstalk
Figure 4 Interactions between adipose, the microbiome and kidney
Nat. Rev. Nephrol. doi: /nrneph
Figure 1 Mechanisms of kidney injury in the setting of obesity
Nat. Rev. Neurol. doi: /nrneurol
Figure 5 Schematic illustration of different clinical trial designs
Figure 2 Proinflammatory mechanisms in CKD
Congestive Heart Failure in Elderly Patients
Nat. Rev. Nephrol. doi: /nrneph
Figure 1 Pathogenic mechanisms and pathways in ADPKD
Nat. Rev. Cardiol. doi: /nrcardio
Figure 1 The genomic nephrology workflow: genetic diagnosis and clinical application Figure 1 |The genomic nephrology workflow: genetic diagnosis and clinical.
Nat. Rev. Nephrol. doi: /nrneph
Figure 7 The efficacy of phosphate-binder therapy
Figure 1 Metabolic profiling as a tool for studying rheumatic diseases
Nat. Rev. Clin. Oncol. doi: /nrclinonc
Figure 5 Risk factor control in the intensive treatment group
Figure 2 The network of chronic diseases and their mutual influences
Figure 1 The burden of chronic kidney disease (CKD)
Moving Further with Medical Tailoring
Nat. Rev. Nephrol. doi: /nrneph
Figure 2 Podocyte dysfunction is a common feature of renal injury
Nat. Rev. Nephrol. doi: /nrneph
Figure 6 Speckle tracking echocardiography to
Nat. Rev. Urol. doi: /nrurol
Figure 3 Possible modalities for reconciliation of patient's and physician's report of symptomatic treatment-associated toxicities Figure 3 | Possible.
Figure 3 Algorithm for the determination of the clinical
Figure 5 Potential roles of phosphate and fibroblast growth factor 23 (FGF-23) in the development of cardiovascular disease in patients with chronic kidney.
Figure 6 Schematic of an analysis of a new biopsy
Nat. Rev. Nephrol. doi: /nrneph
Figure 1 Changes in relative plasma volume (RPV)
Alexandra M. Dainis, and Euan A. Ashley BTS 2018;3:
Figure 5 Examples of biomarker-guided trials
Figure 4 The molecular configuration of the CD20 molecule
Nat. Rev. Neurol. doi: /nrneurol
Nat. Rev. Nephrol. doi: /nrneph
Nat. Rev. Cardiol. doi: /nrcardio
Nat. Rev. Nephrol. doi: /nrneph
the SNP profile using 26 prostate cancer GWAS risk SNPs
Nat. Rev. Nephrol. doi: /nrneph
Figure 6 Hypothetical effect of starting therapy for autosomal
Nat. Rev. Nephrol. doi: /nrneph
Figure 3 Enrichment strategies for clinical trials
Nat. Rev. Nephrol. doi: /nrneph
Figure 3 Preventive strategies for CSA-AKI
Figure 5 Schematic overview of a clinical decision-support
Figure 4 The relationship between the time-dependent changes in the expression of immunoglobulin, mast cell, acute kidney injury (AKI), and fibrillar collagen.
Figure 4 Intracellular distribution and
Figure 4 Radiogenomics analysis can reveal relationships
Figure 1 Overview of the imaging biomarker roadmap
Juan M. Lopez-Gomez, Eduardo Verde, Rafael Perez-Garcia 
Figure 3 Determination of the primary site
(Case 5) Left ventricular hypertrophy—12-lead ECG demonstrating NSR with LVH. The ST segment depression in the lateral leads (I, aVl, V5, and V6) is seen.
Figure 1 Relationships between genetic variants, quantitative traits and diseases Figure 1 | Relationships between genetic variants, quantitative traits.
Diastolic dysfunction in sickle cell
Presentation transcript:

Figure 2 Sources of data to characterize the ADPKD clinical phenotype Figure 2 | Sources of data to characterize the ADPKD clinical phenotype. Beyond vital information obtained from analyses of a patient's medical and family history, molecular genetic and imaging techniques can be used to further characterize the current disease status and prognosis of a patient. Other modalities that can provide clinically relevant information include blood-pressure monitoring and analyses of bodily fluids for the presence of specific biomarkers. LVH, left ventricular hypertrophy. Lanktree, M. B. & Chapman, A. B. (2017) New treatment paradigms for ADPKD: moving towards precision medicine Nat. Rev. Nephrol. doi:10.1038/nrneph.2017.127