Effects of low molecular weight heparin and heparin-binding epidermal growth factor on human trophoblast in first trimester Ying Chen, M.D., Xiao-Xia.

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Effects of low molecular weight heparin and heparin-binding epidermal growth factor on human trophoblast in first trimester Ying Chen, M.D., Xiao-Xia Wu, M.D., Jian-ping Tan, M.D., Mei-lan Liu, M.D., Ying-lin Liu, M.D, Ph.D., Jian-Ping Zhang, M.D. Fertility and Sterility Volume 97, Issue 3, Pages 764-770 (March 2012) DOI: 10.1016/j.fertnstert.2011.12.002 Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) Effects of low molecular weight heparin (LMWH) on trophoblast proliferation. Error bars depict SEM. (B) Effects of LMWH on trophoblast invasion. Error bars depict SEM. (C) Effects of LMWH on trophoblast hCG levels. Error bars depict SEM. ⋆ Compared with group 0 P<.05; Δ compared with group 0 P<.01. Fertility and Sterility 2012 97, 764-770DOI: (10.1016/j.fertnstert.2011.12.002) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Effects of low molecular weight heparin on trophoblast invasion. The invasive index of cells under different conditions was normalized to the control. Microscopic morphologies of the invasion of trophoblasts through the matrigel-coated membranes were taken at magnification ×200. Trophoblast was incubated in the presence of 0.025 IU/mL enoxaparin (0.025), 0.25 IU/mL enoxaparin (0.25), 2.5 IU/mL enoxaparin (2.5), 25 IU/mL enoxaparin (25), 250 IU/mL enoxaparin (250), and control (0). Fertility and Sterility 2012 97, 764-770DOI: (10.1016/j.fertnstert.2011.12.002) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 3 (A) Effects of low molecular weight heparin (LMWH) and heparin-binding epidermal growth factor (HB-EGF) on trophoblast proliferation. Error bars depict SEM (Δ compared with group control P<.01). (B) Effects of LMWH and HB-EGF on trophoblast invasion. Error bars depict SEM (Δ compared with group control P<.01). (C) Effects of LMWH and HB-EGF on hCG levels. Error bars depict SEM (⋆ compared with group control P<.05; Δ compared with group control P<.01). Fertility and Sterility 2012 97, 764-770DOI: (10.1016/j.fertnstert.2011.12.002) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 4 Effects of low molecular weight heparin (LMWH) and heparin-binding epidermal growth factor (HB-EGF) on trophoblast invasion. The invasive index of cells under different conditions was normalized to the control. Microscopic morphologies of the invasion of trophoblasts through the matrigel-coated membranes were taken at magnification ×200. Trophoblast was incubated in the presence of LMWH (0.25 IU/mL enoxaparin), HB-EGF (10 ng/mL HB-EGF), LMWH + HB-EGF (0.25 IU/mL enoxaparin + 10 ng/mL HB-EGF), and control (Dulbecco’s modified Eagle medium [DMEM]). Fertility and Sterility 2012 97, 764-770DOI: (10.1016/j.fertnstert.2011.12.002) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions