Tuberculin skin test conversion and primary progressive tuberculosis disease in the first 5 years of life: a birth cohort study from Cape Town, South.

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Presentation transcript:

Tuberculin skin test conversion and primary progressive tuberculosis disease in the first 5 years of life: a birth cohort study from Cape Town, South Africa Leonardo Martinez, PhD, David M le Roux, MBChB, Whitney Barnett, MPH, Attie Stadler, MBChB, Prof Mark P Nicol, PhD, Heather J Zar, PhD The Lancet Child & Adolescent Health Volume 2, Issue 1, Pages 46-55 (January 2018) DOI: 10.1016/S2352-4642(17)30149-9 Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 1 Study flow *Loss of pregnancy due to miscarriage, stillbirth, or intrauterine death (23 infants [including one set of twins]). †Including four pairs of twins and one set of triplets. ‡No postnatal data collected. §Participants did not have a valid tuberculin skin test result, most commonly because of national tuberculin shortages, but also because mothers and infants did not return for the induration reading. The Lancet Child & Adolescent Health 2018 2, 46-55DOI: (10.1016/S2352-4642(17)30149-9) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 2 Cumulative risk of paediatric tuberculosis and tuberculin skin test conversion *Analysed for the first 3 years of life. The Lancet Child & Adolescent Health 2018 2, 46-55DOI: (10.1016/S2352-4642(17)30149-9) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 3 Adjusted hazard ratios for tuberculosis by number of lower respiratory tract infections in the child Data were analysed using Cox proportional hazard modelling and adjusted for the enrolment site. The Lancet Child & Adolescent Health 2018 2, 46-55DOI: (10.1016/S2352-4642(17)30149-9) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions