Volume 54, Pages S152-S154 (September 1998)

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Volume 54, Pages S152-S154 (September 1998) Pleiotropic effects of hepatocyte growth factor in proximal tubule involve different signaling pathways Peter M. Jehle, Sylvia Stracke, Friedlinde Ernst, Daniela R. Jehle, R. Willi Grunewald, Hermann Haller, Frieder Keller Kidney International Volume 54, Pages S152-S154 (September 1998) DOI: 10.1046/j.1523-1755.1998.06731.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Effects of hepatocyte growth factor (HGF) on PT-1 cell proliferation and differentiation and modulation by different protein tyrosine kinase inhibitors (PTKI). PT-1 cells were grown for 48hours under serum-free conditions in the presence of 1nm HGF alone or in combination with different PTKI at concentrations yielding half-maximal inhibition of cell growth (geldanamycin 0.01 μm, genistein 1 μm, herbimycin A 0.1 μm, and methyl-2,5-dihydroxycinnamate (MDC) 10 μm). (A) Cell proliferation. (B) Cell migration. (C) Formation of tubule structures. (D) Formation of microvilli. Data are means ± sem of six independent experiments. *P < 0.05, **P < 0.01 versus serum-free control. Symbols are: (□) control; (▪) HGF; () HGF + genistein; () HGF + MDC; () HGF + geldanamycin; () HGF + herbimycin A. Kidney International 1998 54, S152-S154DOI: (10.1046/j.1523-1755.1998.06731.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Morphology of PT-1 cells grown for 48hours in serum-free medium alone (A, bar = 10 μm) or in the presence of 1nm hepatocyte growth factor (HGF). (B) HGF-induced cell scattering (thin arrows) and tubulogenesis (thick arrows). Kidney International 1998 54, S152-S154DOI: (10.1046/j.1523-1755.1998.06731.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, S152-S154DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, S152-S154DOI: (10.1046/j.1523-1755.1998.06731.x) Copyright © 1998 International Society of Nephrology Terms and Conditions