Hypothyroidism represses the expression of T3-posivite targets independently of NCoR1. Hypothyroidism represses the expression of T3-posivite targets independently.

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Hypothyroidism represses the expression of T3-posivite targets independently of NCoR1. Hypothyroidism represses the expression of T3-posivite targets independently of NCoR1. Liver mRNA levels of the indicated type 1 genes (A) or type 2 genes (B) in the shown genotypes were measured by qPCR (n = 6 mice per genotype). (C) Dio1 and Thrsp TRβ1-ChIP peaks (6) visualized in genome browser. Arrows indicate the targeted acetylation sites upstream (+) or downstream (−) of TRβ1-ChIP peaks that were used after ChIP with D. H3K9ac ChIP-PCR was run on chromatin of euthyroid and hypothyroid L-NCoR1–KO mice (n = 3 IP per genotype); anti-H3K9 acetyl (07-352; Millipore). (E) DNA libraries from euthyroid and hypothyroid WT and L-NCoR1–KO mice (n = 3 IP per genotype) were used as template for ChIP-PCR. Anti-H3K27ac (catalog no. 39133; Active Motif) was used for immunoprecipitation (IP). Data are shown as mean ± SD; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; two-way ANOVA. Arturo Mendoza et al. PNAS 2017;114:40:E8458-E8467 ©2017 by National Academy of Sciences