Gorav Ailawadi, MD, Brian S. Knipp, MS, Guanyi Lu, MD, PhD, Karen J

Slides:

Advertisements

Similar presentations

Professionalism and the work-life balance Thomas S. Huber, MD, PhD Journal of Vascular Surgery Volume 60, Issue 4, Pages (October 2014) DOI:

Advertisements

Complicated chronic pancreatitis causing mycotic aortic aneurysm: In situ replacement with a cryopreserved aortic allograft Christoph Knosalla, MD, Matthias.

Recurrent thromboembolism in patients with vena cava filters

David W. Lemos, MD, Joseph D. Raffetto, MD, T

Robert J. Pitsch, MD, David J. Minion, MD, Margaret L

Differential expression of Hedgehog/Notch and transforming growth factor-β in human abdominal aortic aneurysms Adam J. Doyle, MD, Eileen M. Redmond,

National trends in venous disease

Pharmacologic blockade and genetic deletion of androgen receptor attenuates aortic aneurysm formation John P. Davis, MD, Morgan Salmon, PhD, Nicolas.

Mark J.W. Koelemay, MD, PhD Journal of Vascular Surgery

Common celiacomesenteric trunk: Aneurysmal and occlusive disease

The accuracy of CT scanning in the diagnosis of abdominal and thoracoabdominal aortic aneurysms George J. Todd, MD, Roman Nowygrod, MD, Alan Benvenisty,

Jay K. Bhama, MD, Peter H. Lin, MD, Theodoros Voloyiannis, MD, Ruth L

Tamoxifen up-regulates catalase production, inhibits vessel wall neutrophil infiltration, and attenuates development of experimental abdominal aortic.

Gorav Ailawadi, MD, Christopher W. Moehle, BS, Hong Pei, MD, Sandra P

Abdominal aortic pseudoaneurysm after blunt trauma

Orally administered dipeptidyl peptidase-4 inhibitor (alogliptin) prevents abdominal aortic aneurysm formation through an antioxidant effect in rats

Asymptomatic internal carotid artery aneurysm

In situ localization and quantification of seventy-two – kilodalton type IV collagenase in aneurysmal, occlusive, and normal aorta William D. McMillan,

Rat and human aortic smooth muscle cells display differing migration and matrix metalloproteinase activities in response to dexamethasone C. Pross, MD,

Differential regulation of matrix metalloproteinase activities in abdominal aortic aneurysms Borhane Annabi, PhD, a, Daniel Shédid, MD, b, Pierre Ghosn,

Clinical relevance of peripheral vascular occlusive disease in patients with rheumatoid arthritis and systemic lupus erythematosus 1 Peter K Henke, MD,

Nicolas H. Pope, MD, Morgan Salmon, PhD, William F

Malcolm O. Perry, MD, Richard Kempczinski, MD

Diffusion of new technology for the treatment of renovascular hypertension in the United States: Surgical revascularization versus catheter-based therapy,

Gary R. Seabrook, MD Journal of Vascular Surgery

A novel rat model of abdominal aortic aneurysm using a combination of intraluminal elastase infusion and extraluminal calcium chloride exposure Akiko.

Infected aneurysm of the thoracic aorta

Palmar hyperhidrosis: Evidence of genetic transmission

Impaired vasoreactivity despite an increase in plasma nitrite in patients with abdominal aortic aneurysms Brian S. Knipp, MS, David A. Peterson, BA,

Recurrent thromboembolism in patients with vena cava filters

Nicholas H. Osborne, MD, Gilbert R. Upchurch, MD, Amit K

Predictors of severe morbidity and death after elective abdominal aortic aneurysmectomy in patients with chronic obstructive pulmonary disease Gilbert.

Retroviral-mediated transduction of endothelial cells with the lac Z gene impairs cellular proliferation in vitro and graft endothelialization in vivo

The differences and similarities between intramural hematoma of the descending aorta and acute type B dissection Jip L. Tolenaar, MD, Kevin M. Harris,

Nitric oxide inhibition increases matrix metalloproteinase–9 expression by rat aortic smooth muscle cells in vitro Gilbert R. Upchurch, MD, John W. Ford,

James Majeski, MD, PhD, E. Stanley Crawford, MD, Elizabeth I

Innovation and science: The future of valve design

Outcomes of an abdominal aortic aneurysm screening program

A first start for lung transplantation?

Perinatal inferior vena cava thrombosis and absence of the infrarenal inferior vena cava Tharumenthiran Ramanathan, MBBS, T. Michael, D. Hughes, FRACS,

Karen Woo, MD, Jens Eldrup-Jorgensen, MD, John W. Hallett, MD, Mark G

Zenia L. Martin, MD, Tara M. Mastracci, MD, Roy K

Douglas Scott Keith, MD, Brian Markey, MD, Michael Schiedler, MD

Gorav Ailawadi, MD, Asheesh Bedi, BS, David M. Williams, MD, James C

S.Amjad Hussain, MD, FRCSC, Ahmet Bayar, MD

Fenton H. McCarthy, MD, MS, Nimesh D. Desai, MD, PhD

Psoas abscess in patients with an infected aortic aneurysm

Reviewer Acknowledgment

Total debranching thoracic endovascular aortic arch repair with inflow from the descending thoracic aorta Yasunori Iida, MD, PhD, Tsutomu Ito, MD, PhD,

Brian M. Cardis, MD, Derek A. Fyfe, MD, PhD, William T. Mahle, MD

Ruptured abdominal aortic aneurysm: A population-based study

Ramesh Lokanathan, MD, FRCS(C), David C. Taylor, MD, FRCS(C)

Surgical treatment of intact thoracoabdominal aortic aneurysms in the United States: Hospital and surgeon volume-related outcomes John A Cowan, MD, Justin.

Comparison of first- and second-generation prostheses for endoluminal repair of abdominal aortic aneurysms: A 6-year study with life table analysis James.

Ruptured thoracoabdominal aortic aneurysm treatment in the United States: 1988 to 1998 John A Cowan, MD, Justin B Dimick, MD, Reid M Wainess, BS, Peter.

Journal of Vascular Surgery

Current concepts in the pathogenesis of abdominal aortic aneurysm

Research and research funding in vascular surgery

Extended use of computed tomography in the management of complex aortic problems: A learning experience Larry R. Williams, M.D. *, William R. Flinn,

Activation of transglutaminase type 2 for aortic wall protection in a rat abdominal aortic aneurysm formation Takashi Munezane, MD, Tomomi Hasegawa,

A biologic basis for asymmetric growth in descending thoracic aortic aneurysms: A role for matrix metalloproteinase 9 and 2 Indranil Sinha, BA, Siddharth.

Conformational changes associated with proximal seal zone failure in abdominal aortic endografts Jose R. Parra, MD, Juan Ayerdi, MD, Robert McLafferty,

The Propranolol Aneurysm Trial Investigators

James A. DeWeese, MD Journal of Vascular Surgery

Thomas L. Forbes, MD, Gregory E.J. Harding, MD

A novel rat model of abdominal aortic aneurysm using a combination of intraluminal elastase infusion and extraluminal calcium chloride exposure Akiko.

Descending thoracic and thoracoabdominal aortic aneurysms: “Busted”

Zone zero thoracic endovascular aortic repair is all about “location, location, location” Kevin L. Greason, MD The Journal of Thoracic and Cardiovascular.

Open repair of abdominal aortic aneurysm in a centenarian

Matthew Thompson, MD, Peter Holt, PhD, Ian Loftus, MD, Thomas L

Presentation transcript:

A nonintrinsic regional basis for increased infrarenal aortic MMP-9 expression and activity Gorav Ailawadi, MD, Brian S. Knipp, MS, Guanyi Lu, MD, PhD, Karen J. Roelofs, DVM, John W. Ford, Kevin K. Hannawa, Keith Bishop, PhD, Porama Thanaporn, Peter K. Henke, MD, James C. Stanley, MD, Gilbert R. Upchurch, MD Journal of Vascular Surgery Volume 37, Issue 5, Pages 1059-1066 (May 2003) DOI: 10.1067/mva.2003.163 Copyright © 2003 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 1 A, RT-PCR for MMP-9 in native aortic segments demonstrates increased expression of MMP-9 in abdominal aorta (Ab) compared with arch (Ar) and descending thoracic aorta (Th). B, Densitometry reveals significantly higher MMP-9 to β-actin mRNA expression in native abdominal aortic segments (Ab) compared with arch (Ar) and descending thoracic (Th) segments. **P <.003, ANOVA; Ar versus Ab, P <.01, Th versus Ab, P <.01, Tukey test. Journal of Vascular Surgery 2003 37, 1059-1066DOI: (10.1067/mva.2003.163) Copyright © 2003 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 2 A, MMP-2 expression in native rat aortas is similar among aortic segments (P =.95). B, TIMP-1 expression in native rat aortas is not different between aortic segments (P =.12). Journal of Vascular Surgery 2003 37, 1059-1066DOI: (10.1067/mva.2003.163) Copyright © 2003 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 3 A, Gelatin zymogram of native rat aortic segments. Higher activity levels of pro-MMP-9 and active MMP-9 in abdominal (Ab) segments versus arch (Ar) and descending thoracic (Th) aortic segments. B, Densitometry measurements demonstrate significantly higher total MMP-9 activity in Ab segment compared with Ar and Th aortic segments. *P <.023, ANOVA; Ab versus Th, P <.05, Tukey test. Journal of Vascular Surgery 2003 37, 1059-1066DOI: (10.1067/mva.2003.163) Copyright © 2003 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 4 A, RT-PCR evidence of increased MMP-9 expression in transplanted (TxTh) aortic segments compared with corresponding nontransplanted arch (Ar) and descending thoracic (Th) aortic segments. **P <.004, ANOVA; Ar versus TxTh, P <.01, Th versus TxTh, P <.05, Tukey test. B, RT-PCR evidence of increased MMP-9 expression in TxAb aortic segments compared with corresponding nontransplanted Ar and Th aortic segments. *P <.05, ANOVA; Th versus Ab, P <.05, Tukey test. C, MMP-9 expression of transplanted abdominal segments (TxAb), transplanted thoracic segments (TxTh), and native infrarenal aortic segments (Ab). No differences were evident (P =.96). Journal of Vascular Surgery 2003 37, 1059-1066DOI: (10.1067/mva.2003.163) Copyright © 2003 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 5 A, Gelatin zymography evidence of increased total MMP-9 activity in transplanted abdominal (TxAb) aortic segments compared with nontransplanted arch (Ar) and descending thoracic (Th) aortic segments. *P <.013, ANOVA; Th versus TxTh, P <.05, Ar versus TxTh, P <.05, Tukey test. B, Gelatin zymography evidence increased total MMP-9 activity in transplanted abdominal (TxAb) aortic segments compared with nontransplanted arch (Ar) and descending thoracic (Th) aortic segments. *P <.05, ANOVA; Th versus Ab, P <.05. Journal of Vascular Surgery 2003 37, 1059-1066DOI: (10.1067/mva.2003.163) Copyright © 2003 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 6 H&E staining of native thoracic (A), native abdominal (B), transplanted thoracic (C), and transplanted abdominal (D) aortic segments. No differences in mononuclear cell count were noted between native thoracic and abdominal aortic segments or between transplanted segments. Differences between native and transplanted segments were demonstrated. Journal of Vascular Surgery 2003 37, 1059-1066DOI: (10.1067/mva.2003.163) Copyright © 2003 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions