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Volume 3, Issue 7, Pages 619-627 (July 2016) Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study Dr Robin L Carhart-Harris, PhD, Mark Bolstridge, MD, James Rucker, MD, Camilla M J Day, MD, David Erritzoe, MD, Mendel Kaelen, BSc, Michael Bloomfield, MD, James A Rickard, PhD, Prof Ben Forbes, PhD, Amanda Feilding, Prof David Taylor, PhD, Prof Steve Pilling, PhD, Prof Valerie H Curran, PhD, Prof David J Nutt, DM The Lancet Psychiatry Volume 3, Issue 7, Pages 619-627 (July 2016) DOI: 10.1016/S2215-0366(16)30065-7 Copyright © 2016 Carhart-Harris et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 1 Schedule of study interventions The Lancet Psychiatry 2016 3, 619-627DOI: (10.1016/S2215-0366(16)30065-7) Copyright © 2016 Carhart-Harris et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Trial profile The Lancet Psychiatry 2016 3, 619-627DOI: (10.1016/S2215-0366(16)30065-7) Copyright © 2016 Carhart-Harris et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 3 Mean depression severity (QIDS) over time Depression severity determined by self-rated 16-item QIDS. QIDS scores of 16–20 are considered to reflect severe depression, scores of 11–15 are considered moderate depression, scores of 6–10 are considered mild depression, and scores of 5 and less are considered absent depression. All post-treatment assessments were obtained after the high-dose session (ie, 1 week post-treatment refers to 1 week after the high-dose session). Hedges' g values versus baseline are shown. QIDS=Quick Inventory of Depressive Symptoms. The Lancet Psychiatry 2016 3, 619-627DOI: (10.1016/S2215-0366(16)30065-7) Copyright © 2016 Carhart-Harris et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 4 Depression severity (BDI) over time, by patient Figure shows depression severity (BDI) over time plotted for each of the 12 patients. Mean values (SD) are shown as well as the relevant effect sizes (Hedges' g) versus baseline. BDI=Beck Depression Inventory. The Lancet Psychiatry 2016 3, 619-627DOI: (10.1016/S2215-0366(16)30065-7) Copyright © 2016 Carhart-Harris et al. Open Access article distributed under the terms of CC BY Terms and Conditions