A. Duma, C. Wagner, M. Titz, M. Maleczek, M. Hüpfl, V. B. Weihs, E

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High-sensitivity cardiac troponin T in young, healthy adults undergoing non-cardiac surgery A. Duma, C. Wagner, M. Titz, M. Maleczek, M. Hüpfl, V.B. Weihs, E. Samaha, H. Herkner, T. Szekeres, M. Mittlboeck, M.G. Scott, A.S. Jaffe, P. Nagele British Journal of Anaesthesia Volume 120, Issue 2, Pages 291-298 (February 2018) DOI: 10.1016/j.bja.2017.09.001 Copyright © 2017 British Journal of Anaesthesia Terms and Conditions

Fig 1 Flow diagram that shows the process of enrollment and exclusion. POD 0, plasma sample obtained 2–6 h after surgery on POD 0; POD 1, plasma sample obtained 18–30 h after surgery on POD 1. POD, postoperative day. British Journal of Anaesthesia 2018 120, 291-298DOI: (10.1016/j.bja.2017.09.001) Copyright © 2017 British Journal of Anaesthesia Terms and Conditions

Fig 2 Box plots with Tukey's whiskers of the (a) relative and (c) absolute perioperative peak increase (median and lower quartile coincide in both box plots). (b) and (d) The relative and absolute increase of each individual patient is plotted as a line. cTnT, cardiac troponin T; POD, postoperative day; preOP, before surgery. British Journal of Anaesthesia 2018 120, 291-298DOI: (10.1016/j.bja.2017.09.001) Copyright © 2017 British Journal of Anaesthesia Terms and Conditions

Fig 3 Individual hscTnT concentrations at observed time points. hscTnT, high-sensitivity cardiac troponin T. British Journal of Anaesthesia 2018 120, 291-298DOI: (10.1016/j.bja.2017.09.001) Copyright © 2017 British Journal of Anaesthesia Terms and Conditions

Fig 4 Box plots with Tukey's whiskers of preoperative and postoperative hscTnT concentrations. There was no significant perioperative increase of hscTnT concentrations in young, healthy adults undergoing non-cardiac surgery (Friedman anova: P=0.1). Red dots show outliers above the sex-specific 99th URL. PREOP, preoperative hscTnT concentrations; POD 0, hscTnT concentrations on POD 0; POD 1, hscTnT concentrations on POD 1. anova, analysis of variance; hscTnT, high-sensitivity cardiac troponin T; POD, postoperative day. British Journal of Anaesthesia 2018 120, 291-298DOI: (10.1016/j.bja.2017.09.001) Copyright © 2017 British Journal of Anaesthesia Terms and Conditions