Prognostic value of interferon-γ release assays and tuberculin skin test in predicting the development of active tuberculosis (UK PREDICT TB): a prospective.

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Prognostic value of interferon-γ release assays and tuberculin skin test in predicting the development of active tuberculosis (UK PREDICT TB): a prospective cohort study Prof Ibrahim Abubakar, PhD, Prof Francis Drobniewski, PhD, Jo Southern, PhD, Alice J Sitch, MSc, Charlotte Jackson, PhD, Marc Lipman, FRCP, Prof Jonathan J Deeks, PhD, Prof Chris Griffiths, FRCP, Prof Graham Bothamley, PhD, William Lynn, FRCP, Helen Burgess, MBBS, Bobby Mann, FRCP, Ambreen Imran, MSc, Saranya Sridhar, DSc, Chuen-Yan Tsou, MSc, Vladyslav Nikolayevskyy, PhD, Melanie Rees-Roberts, PhD, Hilary Whitworth, PhD, Prof Onn Min Kon, FRCP, Pranab Haldar, MD, Heinke Kunst, MD, Sarah Anderson, MD, Prof Andrew Hayward, MD, Prof John M Watson, FRCP, Prof Heather Milburn, FRCP, Prof Ajit Lalvani, DM D Adeboyeku, N Bari, J Barker, H Booth, F Chua, D Creer, M Darmalingam, R N Davidson, M Dedicoat, A Dunleavy, J Figueroa, M Haseldean, N Johnson, S Losewicz, J Lord, J Moore-Gillon, G Packe, M Pareek, S Tiberi, A Pozniak, F Sanderson Prof Ibrahim Abubakar, PhD, Prof Francis Drobniewski, PhD, Jo Southern, PhD, Alice J Sitch, MSc, Charlotte Jackson, PhD, Marc Lipman, FRCP, Prof Jonathan J Deeks, PhD, Prof Chris Griffiths, FRCP, Prof Graham Bothamley, PhD, William Lynn, FRCP, Helen Burgess, MBBS, Bobby Mann, FRCP, Ambreen Imran, MSc, Saranya Sridhar, DSc, Chuen-Yan Tsou, MSc, Vladyslav Nikolayevskyy, PhD, Melanie Rees-Roberts, PhD, Hilary Whitworth, PhD, Prof Onn Min Kon, FRCP, Pranab Haldar, MD, Heinke Kunst, MD, Sarah Anderson, MD, Prof Andrew Hayward, MD, Prof John M Watson, FRCP, Prof Heather Milburn, FRCP, Prof Ajit Lalvani, DM D Adeboyeku, N Bari, J Barker, H Booth, F Chua, D Creer, M Darmalingam, R N Davidson, M Dedicoat, A Dunleavy, J Figueroa, M Haseldean, N Johnson, S Losewicz, J Lord, J Moore-Gillon, G Packe, M Pareek, S Tiberi, A Pozniak, F Sanderson The Lancet Infectious Diseases Volume 18, Issue 10, Pages 1077-1087 (October 2018) DOI: 10.1016/S1473-3099(18)30355-4 Copyright © 2018 Authors(s). This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

Figure 1 Study profile of tests and results Of 9610 tested participants, 97 (1·0%) progressed to active tuberculosis, and 6380 (66·4%) completed all tests and follow-up (data allowing follow-up to be calculated were missing for six participants). Of the 6380 who completed all tests and follow-up (for whom we had data), 77 (1·2%) progressed to active tuberculosis. The Lancet Infectious Diseases 2018 18, 1077-1087DOI: (10.1016/S1473-3099(18)30355-4) Copyright © 2018 Authors(s). This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

Figure 2 Time to progression to tuberculosis in all participants (A) and according to tuberculosis test result (B–F) Lines are estimates, with 95% CIs as the shaded area. Data are shown for per-protocol population. Scale for cumulative progression to tuberculosis in panel A is greater than in B–F. The Lancet Infectious Diseases 2018 18, 1077-1087DOI: (10.1016/S1473-3099(18)30355-4) Copyright © 2018 Authors(s). This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions