Early Failure of Frontline Rituximab-Containing Chemo-immunotherapy in Diffuse Large B Cell Lymphoma Does Not Predict Futility of Autologous Hematopoietic.

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Early Failure of Frontline Rituximab-Containing Chemo-immunotherapy in Diffuse Large B Cell Lymphoma Does Not Predict Futility of Autologous Hematopoietic Cell Transplantation Mehdi Hamadani, Parameswaran N. Hari, Ying Zhang, Jeanette Carreras, Görgün Akpek, Mahmoud D. Aljurf, Ernesto Ayala, Veronika Bachanova, Andy I. Chen, Yi-Bin Chen, Luciano J. Costa, Timothy S. Fenske, César O. Freytes, Siddhartha Ganguly, Mark S. Hertzberg, Leona A. Holmberg, David J. Inwards, Rammurti T. Kamble, Edward J. Kanfer, Hillard M. Lazarus, David I. Marks, Taiga Nishihori, Richard Olsson, Nishitha M. Reddy, David A. Rizzieri, Bipin N. Savani, Melhem Solh, Julie M. Vose, Baldeep Wirk, David G. Maloney, Sonali M. Smith, Silvia Montoto, Wael Saber Biology of Blood and Marrow Transplantation Volume 20, Issue 11, Pages 1729-1736 (November 2014) DOI: 10.1016/j.bbmt.2014.06.036 Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Autologous transplantation outcomes for DLBCL, relative to the timing of rituximab failure. (A) Cumulative incidence of NRM, (B) cumulative incidence of disease progression/relapse, (C) PFS, and (D) OS. LRF is indicated by interrupted curves; ERF, solid curves. Biology of Blood and Marrow Transplantation 2014 20, 1729-1736DOI: (10.1016/j.bbmt.2014.06.036) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 (A) PFS and (B) OS of ERF DLBCL patients with primary refractory disease (solid curve), compared with DLBCL relapsing within 12 months of initial diagnosis (interrupted curve). Biology of Blood and Marrow Transplantation 2014 20, 1729-1736DOI: (10.1016/j.bbmt.2014.06.036) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions