A rational approach to fluid therapy in sepsis

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A rational approach to fluid therapy in sepsis P. Marik, R. Bellomo British Journal of Anaesthesia Volume 116, Issue 3, Pages 339-349 (March 2016) DOI: 10.1093/bja/aev349 Copyright © 2016 The Author(s) Terms and Conditions

Fig 1 Superimposition of the Frank-Starling and Marik-Phillips curves demonstrating the effects of increasing preload on stroke volume and lung water in a patient who is pre-load responsive (a) and non-responsive (b). With sepsis the EVLW curve is shifted to the left.51 EVLW+extra-vascular lung water; CO+cardiac output; SV+stroke volume. MCFP+mean circulating filling pressure. Reproduced with permission from the British Journal Anaesthesia; 2014;12:620–622. British Journal of Anaesthesia 2016 116, 339-349DOI: (10.1093/bja/aev349) Copyright © 2016 The Author(s) Terms and Conditions

Fig 2 Fluid administered between enrolment and 72 h and 90-day mortality in the control arm of the Early Goal Directed Therapy (EGDT) Studies performed between 2001 and 2015. APACHE II+APACHE II Severity of illness scoring system (0–71). British Journal of Anaesthesia 2016 116, 339-349DOI: (10.1093/bja/aev349) Copyright © 2016 The Author(s) Terms and Conditions

Fig 3 Fluid administered between enrolment and 6 h and central venous pressure (CVP) at h in the Early Goal Directed arm of the EGDT studies performed between 2001 and 2015. British Journal of Anaesthesia 2016 116, 339-349DOI: (10.1093/bja/aev349) Copyright © 2016 The Author(s) Terms and Conditions