Experimental Hematology

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Presentation transcript:

Experimental Hematology Adult T-type lymphoblastic lymphoma: Treatment advances and prognostic indicators  Stéphane Lepretre, Carlos Graux, Aurore Touzart, Elizabeth Macintyre, Nicolas Boissel  Experimental Hematology  Volume 51, Pages 7-16 (July 2017) DOI: 10.1016/j.exphem.2017.04.002 Copyright © 2017 ISEH - International Society for Experimental Hematology Terms and Conditions

Figure 1 Treatment protocol in the GRAALL-LYSA LL03 study. The GRAALL-LYSA LL03 protocol consisted of a corticosteroid prephase, a five-drug induction with sequential administration of cyclophosphamide (hyperC sequence), dose-dense consolidation, late intensification, CNS prophylaxis with intrathecal chemotherapy and cranial irradiation, and a 2-year maintenance phase [36]. Allogeneic SCT was offered in first CR or unconfirmed CR to patients with high-risk disease who had a suitable donor. Ara-C = cytarabine; CPM = cyclophosphamide; DNR = daunorubicin; DXM = dexamethasone; G-CSF = granulocyte colony-stimulating factor (lenograstim); IDA = idarubicin; i.t. = intrathecal; L-asp = L-asparaginase; MPDN = methylprednisolone; MTX = methotrexate; PDN = prednisone; VCR = vincristine; VP-16 = etoposide; 6-MP = 6-mercaptopurine. Experimental Hematology 2017 51, 7-16DOI: (10.1016/j.exphem.2017.04.002) Copyright © 2017 ISEH - International Society for Experimental Hematology Terms and Conditions

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