Observed (symbols) and model predicted (lines) dopamine time courses in rats following D-amphetamine administration. Observed (symbols) and model predicted.

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Observed (symbols) and model predicted (lines) dopamine time courses in rats following D-amphetamine administration. Observed (symbols) and model predicted (lines) dopamine time courses in rats following D-amphetamine administration. Figures A – C doses to rats were 0.1 mg/kg (black circles), 1 mg/kg (red diamonds, reference 17), 2.5 mg/kg (green squares, Melega et al., 1995), 5 mg/kg (open blue triangles, solid line for study 1, Melega et al., 1995, and open blue triangles, dashed line for study 2, Bardo et al., 1999). Figures D – F doses to rats were 0.5 mg/kg (open black circles), 1 mg/kg (red diamonds), 2 mg/kg (green closed circles), 2.5 mg/kg (blue squares), 5 mg/kg (black triangles), all from Melega et al., 1995. Doses are as reported in the original work (see Supplemental Table 1 for details). Figures A and D represent no moderator component, Figures B and E represent a response-independent moderator component, and Figures C and F represent a response-adjusted moderator component in the model. Marcel M. van Gaalen et al. J Pharmacol Exp Ther 2019;369:107-120 Copyright © 2019 The Author(s).