Poly-ADP-ribose polymerase inhibition protects against myocardial and endothelial reperfusion injury after hypothermic cardiac arrest Gábor Szabó, MD,

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Presentation transcript:

Poly-ADP-ribose polymerase inhibition protects against myocardial and endothelial reperfusion injury after hypothermic cardiac arrest Gábor Szabó, MD, PhD, Volker Buhmann, MS, Terézia Andrási, MD, Nicole Stumpf, MTA, Susanne Bährle, MD, Violetta Kékesi, PhD, Siegfried Hagl, MD, Csaba Szabó, MD, PhD, Alexander Juhász-Nagy, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 126, Issue 3, Pages 651-658 (September 2003) DOI: 10.1016/S0022-5223(02)73235-2

Figure 1 Percentage change of Ees, slope of the left ventricular dP/dtmax-end-diastolic volume relationship, and preload recruitable stroke work after CPB at 60 minutes of reperfusion. All values are given as means ± SEM. ∗P < .05, PJ34 versus control. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 651-658DOI: (10.1016/S0022-5223(02)73235-2)

Figure 2 RVEDV (A), RVEDP (B), RVESV (C), and slope of right ventrciular Ees (RV Ees; D) as a function of RVSP before and after CPB at 60 minutes of reperfusion. All values are given as means ± SEM. ∗P < .05 versus other runs. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 651-658DOI: (10.1016/S0022-5223(02)73235-2)

Figure 3 Coronary blood flow before and after CPB at 60 minutes of reperfusion. All values are given as means ± SEM. ○P < .05 versus baseline; ∗P < .05 PJ34 versus control. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 651-658DOI: (10.1016/S0022-5223(02)73235-2)

Figure 4 Coronary vascular function. Endothelium-dependent vasodilatation after acetylcholine (ACH; 10−7 mol/L, left panel) and endothelium-independent vasodilatation after sodium nitroprusside (SNP; 10−4 mol/L; right panel). All values are given as means ± SEM. ○P < .05 versus baseline; ∗P < .05, PJ34 versus control. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 651-658DOI: (10.1016/S0022-5223(02)73235-2)

Dr Szabó The Journal of Thoracic and Cardiovascular Surgery 2003 126, 651-658DOI: (10.1016/S0022-5223(02)73235-2)