The adenylate cyclase toxin of Bacillus anthracis is a potent promoter of TH17 cell development Silvia Rossi Paccani, PhD, Marisa Benagiano, PhD, Maria.

Slides:

Advertisements

Similar presentations

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,

Advertisements

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Maria B. Sukkar, PhD, Shaoping Xie, PhD, Nadia M

The human polysaccharide- and protein-specific immune response to Streptococcus pneumoniae is dependent on CD4+ T lymphocytes, CD14+ monocytes, and the.

Identification of drug- and drug-metabolite immune responses originating from both naive and memory T cells Andrew Gibson, MRes, Lee Faulkner, PhD, Sally.

Clarification concerning amoxicillin skin testing

Fatty acids, inflammation, and asthma

Induction of anergic allergen-specific suppressor T cells using tolerogenic dendritic cells derived from children with allergies to house dust mites

CD39: A new surface marker of mouse regulatory γδ T cells

Jelle de Wit, PhD, M. Hussein Al-Mossawi, MD, Michael H

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Human B cells promote T-cell plasticity to optimize antibody response by inducing coexpression of TH1/TFH signatures Jelle de Wit, PhD, Tineke Jorritsma,

Major rabbit allergen Ory c 3: What could be its possible role as a sensitizing agent in real life? Gennaro Liccardi, MD, Antonello Salzillo, MD, Maria.

Is 9 more than 2 also in allergic airway inflammation?

Desensitization to Chemotherapeutic Agents

Fatty acids, inflammation, and asthma

TNF-α–induced protein 3 (A20): The immunological rheostat

Keith J. Simons, PhD, Margherita Strolin Benedetti, PhD, F. Estelle R

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Yuichi Teraki, MD, Aika Sakurai, MD, Seiichi Izaki, MD

Physician needs in health informatics: Just ask the docs

Nonadherence to Asthma Treatment: Getting Unstuck

William J. Calhoun, MD, Tmirah Haselkorn, PhD, Dave P

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

IL-5 T-cell responses to house dust mite are associated with the development of allergen-specific IgE responses and asthma in the first 5 years of life

Reply Journal of Allergy and Clinical Immunology

The Editors' Choice Journal of Allergy and Clinical Immunology

Identification of drug- and drug-metabolite immune responses originating from both naive and memory T cells Andrew Gibson, MRes, Lee Faulkner, PhD, Sally.

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A

Update on the role of prostaglandins in allergic lung inflammation: Separating friends from foes, harder than you might think Martin L. Moore, PhD, R.

In vivo maturation of TH cells in relation to atopy

What is an “eosinophilic phenotype” of asthma?

Cephalosporin Side Chain Cross-reactivity

Liam O’Mahony, PhD, Mübeccel Akdis, MD, PhD, Cezmi A. Akdis, MD

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

IL-2– and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets Sven Létourneau, DPhil, Carsten Krieg, PhD, Giuseppe Pantaleo,

News & Notes Journal of Allergy and Clinical Immunology

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Advances in the approach to the patient with food allergy

Lei Wang, MD, PhD, Jesse P. Joad, MD, Caiyun Zhong, MD, PhD, Kent E

Matthew J. Loza, PhD, Susan Foster, PhD, Stephen P

New pathways for itching in patients with atopic dermatitis?

The human polysaccharide- and protein-specific immune response to Streptococcus pneumoniae is dependent on CD4+ T lymphocytes, CD14+ monocytes, and the.

Prevention of food allergy: Beyond peanut

News Beyond Our Pages Journal of Allergy and Clinical Immunology

One step forward, 2 steps back: The enigma of preschool wheeze

Benjamin Chaigne, MD, Hervé Watier, MD, PhD

Xiu-Min Li, MD, LaVerne Brown, PhD

Thunderstorm-related asthma attacks

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Advances in basic and clinical immunology in 2013

Measles and immunomodulation

Human basophils may not undergo modulation by DC-SIGN and mannose receptor– targeting immunotherapies due to absence of receptors Mrinmoy Das, MSc, Caroline.

Macrolide antibiotics and asthma treatment

Asthma: The past, future, environment, and costs

Interrupting IL-6–receptor signaling improves atopic dermatitis but associates with bacterial superinfection Alexander A. Navarini, MD, PhD, Lars E.

Janet Chou, MD, Maxim Lutskiy, MD, PhD, Erdyni Tsitsikov, PhD, Luigi D

Environmental factors and eosinophilic esophagitis

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Safety and efficacy of repeated monthly carboplatin desensitization

Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease Jaclyn Smith, MD, PhD, Emily Owen, MPhil, John Earis, MD,

Natural history of cow’s milk allergy

Perturbations of natural killer cell regulatory functions in respiratory allergic diseases Francesca Scordamaglia, MD, Mirna Balsamo, PhD, Antonio Scordamaglia,

Induction of anergic allergen-specific suppressor T cells using tolerogenic dendritic cells derived from children with allergies to house dust mites

Primary prevention of asthma and allergy

Itching as a systemic disease

Presentation transcript:

The adenylate cyclase toxin of Bacillus anthracis is a potent promoter of TH17 cell development Silvia Rossi Paccani, PhD, Marisa Benagiano, PhD, Maria Teresa Savino, PhD, Francesca Finetti, PhD, Fiorella Tonello, PhD, Mario M. D’Elios, MD, Cosima T. Baldari, PhD Journal of Allergy and Clinical Immunology Volume 127, Issue 6, Pages 1635-1637 (June 2011) DOI: 10.1016/j.jaci.2010.12.1104 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 ET promotes TH17 cell polarization through its cAMP-increasing activity. A, Quantification of IL-17, IL-21, IL-22, and relative mRNA levels of retinoic acid receptor–related orphan receptor γ (RORγ), IL-23 receptor, IL-1β receptor (A), IL-4 (B), or IFN-γ (C) in T cells (2-4 donors, duplicate samples) primed in the presence or absence of ET/EL1 or CyaA/CyaA-E5 and restimulated with anti-CD3 mAb for 24 hours. Error bars = SDs. Journal of Allergy and Clinical Immunology 2011 127, 1635-1637DOI: (10.1016/j.jaci.2010.12.1104) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions