A Sequel to the Tale of p25/Cdk5 in Neurodegeneration

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A Sequel to the Tale of p25/Cdk5 in Neurodegeneration Burcin Ikiz, Serge Przedborski Neuron Volume 60, Issue 5, Pages 731-732 (December 2008) DOI: 10.1016/j.neuron.2008.11.020 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Unifying Pathogenic Scenario for Aberrant p25/Cdk5-Mediated Neurodegeneration Abnormal production of p25 and activation of Cdk5 may be linked to Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), ischemia, and Alzheimer's disease (AD). The role of p25/Cdk5 in each of these different conditions has been related to unique signaling events as indicated. Collectively, these cellular perturbations culminate in the demise of the affected cells, likely by apoptosis. Neuron 2008 60, 731-732DOI: (10.1016/j.neuron.2008.11.020) Copyright © 2008 Elsevier Inc. Terms and Conditions