Erythropoietin activates the phosporylated cAMP [adenosine 3′5′ cyclic monophosphate] response element-binding protein pathway and attenuates delayed.

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Presentation transcript:

Erythropoietin activates the phosporylated cAMP [adenosine 3′5′ cyclic monophosphate] response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury Joshua M. Mares, BA, Lisa S. Foley, MD, Marshall T. Bell, MD, Daine T. Bennett, MD, Kirsten A. Freeman, MD, Xianzhong Meng, MD, PhD, Michael J. Weyant, MD, Joseph C. Cleveland, MD, David A. Fullerton, MD, Ferenc Puskas, MD, Thomas Brett Reece, MD The Journal of Thoracic and Cardiovascular Surgery Volume 149, Issue 3, Pages 920-924 (March 2015) DOI: 10.1016/j.jtcvs.2014.11.011 Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Hind-limb function, as measured by Basso score in the first 48 hours after surgery. EPO, Erythropoietin; IR, ischemia reperfusion. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 920-924DOI: (10.1016/j.jtcvs.2014.11.011) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Histologic analysis, using hemotoxylin and eosin stains, of the spinal cord cross-sections, shows a significant reduction in neuronal viability in control mice subjected to spinal cord ischemia and reperfusion. IR, Ischemia reperfusion; EPO, erythropoietin. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 920-924DOI: (10.1016/j.jtcvs.2014.11.011) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Levels of activated AKT and activated CREB protein expression after EPO treatment. AKT, Serine/threonine-specific kinase; CREB, cAMP [adenosine 3′5′ cyclic monophosphate] response element-binding protein; pAKT, phosphorylated AKT; pCREB, phosphorylated CREB; IR, ischemia reperfusion; NS, nonsignificant; EPO, erythropoietin. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 920-924DOI: (10.1016/j.jtcvs.2014.11.011) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Levels of BCL-2 and BDNF at 12 and 24 hours. BCL-2, B-cell lymphoma 2; BDNF, brain-derived neurotrophic factor; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; NS, nonsignificant; EPO, erythropoietin. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 920-924DOI: (10.1016/j.jtcvs.2014.11.011) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions