Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Simultaneously increased fraction of exhaled nitric oxide levels and blood eosinophil counts relate to increased asthma morbidity Andrei Malinovschi,

Risk of an asthma exacerbation after bariatric surgery in adults

Anne M. Fitzpatrick, PhD, MSCR, W. Gerald Teague, MD

Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes Annette T. Hastie, PhD, Wendy C. Moore,

Treatment of hypogammaglobulinemia in adults: A scoring system to guide decisions on immunoglobulin replacement Shradha Agarwal, MD, Charlotte Cunningham-Rundles,

Increased phenotypic differentiation and reduced corticosteroid sensitivity of fibrocytes in severe asthma Chun-Yu Lo, MD, Charalambos Michaeloudes,

Obstructive sleep apnea syndrome and inflammation

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids Kittipong Maneechotesuwan, MD, PhD, Sirinya.

Immunologic defects in 22q11.2 deletion syndrome

Treatment of hypogammaglobulinemia in adults: A scoring system to guide decisions on immunoglobulin replacement Shradha Agarwal, MD, Charlotte Cunningham-Rundles,

Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD

Is 9 more than 2 also in allergic airway inflammation?

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Suzana Radulovic, MD, Mikila R. Jacobson, PhD, Stephen R

Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing.

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Despo Ierodiakonou, MD, Dirkje S. Postma, MD, PhD, Gerard H

The risk of asthma exacerbation after stopping low-dose inhaled corticosteroids: A systematic review and meta-analysis of randomized controlled trials

A network-based analysis of the late-phase reaction of the skin

Peter M. Wolfgram, MD, David B. Allen, MD

Airway hyperresponsiveness in chronic obstructive pulmonary disease: A marker of asthma-chronic obstructive pulmonary disease overlap syndrome? Ruzena.

Prenatal and postnatal genetic influence on lung function development

Alvin W. L. Schadenberg, MD, Theo van den Broek, MD, Marten A

Serum tryptase levels in atopic and nonatopic children

Ronald L. Sorkness, PhD, Edward M

Possible role of TH17 cells in the pathogenesis of Stevens-Johnson syndrome and toxic epidermal necrolysis Yuichi Teraki, MD, Misaki Kawabe, MD, Seiichi.

Nasal epithelium as a proxy for bronchial epithelium for smoking-induced gene expression and expression Quantitative Trait Loci Kai Imkamp, MD, Marijn.

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase

Augmented epithelial endothelin-1 expression in refractory asthma

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Claus Bachert, MD, PhD, Cezmi A. Akdis, MD

Lisa G. Wood, PhD, Manohar L. Garg, PhD, Peter G. Gibson, MBBS

CC chemokine receptors CCR1 and CCR4 are expressed on airway mast cells in allergic asthma Kawa Amin, PhD, Christer Janson, MD, PhD, Ilkka Harvima, MD,

What is an “eosinophilic phenotype” of asthma?

Increased sputum endotoxin levels are associated with an impaired lung function response to oral steroids in asthmatic patients Charles McSharry, PhD,

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Perinatal risk factors for bronchial hyperresponsiveness and atopy after a follow-up of 20 years Judith M Vonk, MSc, H.Marike Boezen, PhD, Dirkje S Postma,

Matthew J. Loza, PhD, Susan Foster, PhD, Stephen P

Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L

The gastrointestinal tract is critical to the pathogenesis of acute HIV-1 infection Saurabh Mehandru, MD, Klara Tenner-Racz, MD, Paul Racz, MD, PhD, Martin.

Revisiting the Dutch hypothesis

Martin Brasholt, MD, Florent Baty, PhD, Hans Bisgaard, MD, DMSci

Biju Thomas, MD, Robert Anthony Hirst, PhD, Mina H

Frederika A. van Nimwegen, MSc, John Penders, PhD, Ellen E

Jessica H. Savage, MD, MHS, Elizabeth C. Matsui, MD, MHS, Robert A

Usa Tantibhaedhyangkul, MD, Carla M. Davis, MD, Lenora M

Human basophils may not undergo modulation by DC-SIGN and mannose receptor– targeting immunotherapies due to absence of receptors Mrinmoy Das, MSc, Caroline.

IL-9 and c-Kit+ mast cells in allergic rhinitis during seasonal allergen exposure: Effect of immunotherapy Kayhan T. Nouri-Aria, PhD, FRCPath, Charles.

Macrolide antibiotics and asthma treatment

Asthma: The past, future, environment, and costs

Janet Chou, MD, Maxim Lutskiy, MD, PhD, Erdyni Tsitsikov, PhD, Luigi D

Dendritic cells in nasal mucosa of subjects with different allergic sensitizations Susanne M. Reinartz, MD, Joost van Tongeren, MD, Danielle van Egmond,

Environmental factors and eosinophilic esophagitis

Valérie Bougault, PhD, Julie Turmel, MSc, Louis-Philippe Boulet, MD

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Small-airways dysfunction associates with respiratory symptoms and clinical features of asthma: A systematic review Erica van der Wiel, MD, Nick H.T.

Negative affect, medication adherence, and asthma control in children

Natural history of cow’s milk allergy

Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids Kittipong Maneechotesuwan, MD, PhD, Sirinya.

Primary prevention of asthma and allergy

Presentation transcript:

Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways Christina Draijer, PhD, Carian E. Boorsma, MSc, Patricia Robbe, PhD, Wim Timens, MD, PhD, Machteld N. Hylkema, PhD, Nick H. Ten Hacken, MD, PhD, Maarten van den Berge, MD, PhD, Dirkje S. Postma, MD, PhD, Barbro N. Melgert, PhD Journal of Allergy and Clinical Immunology Volume 140, Issue 1, Pages 280-283.e3 (July 2017) DOI: 10.1016/j.jaci.2016.11.020 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Aligned dot plots with line shown at median of macrophages in bronchial biopsies of healthy subjects and males and females with asthma. Number of all CD68+ cells (A), IRF5+CD68+ (B), CD206+CD68+ (C), and IL-10+CD68+ cells (D). Linear regression of IRF5+CD68+ cells (E) and FEV1/FVC ratio, and IL-10+CD68+ cells (F) and FEV1/FVC ratio in patients with asthma. Number of IRF5+CD68+ cells and CD206+CD68+ cells in male and female patients with asthma with a lower FEV1 than 85%predicted (G and I) and with a higher FEV1 than 85%predicted (H and J). Number of all CD68+ cells (K), IRF5+CD68+ (L), CD206+CD68+ (M), and IL-10+CD68+ cells (N) in healthy subjects and patients with asthma using ICS and not using ICS. FVC, Forced vital capacity. Journal of Allergy and Clinical Immunology 2017 140, 280-283.e3DOI: (10.1016/j.jaci.2016.11.020) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Representative photos of IRF5+CD68+ (A), CD206+CD68+ (B), and IL-10+CD68+ cells (C) (magnification 200×). Journal of Allergy and Clinical Immunology 2017 140, 280-283.e3DOI: (10.1016/j.jaci.2016.11.020) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions