Spontaneous development of sclerotic changes of subchondral bone and cartilage degradation in endothelin-1 overexpression transgenic mice upon high fat/high.

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Presentation transcript:

Spontaneous development of sclerotic changes of subchondral bone and cartilage degradation in endothelin-1 overexpression transgenic mice upon high fat/high cholesterol diet P.B. Chan, C. Wen, C. Yan, K. Chiu Osteoarthritis and Cartilage Volume 23, Pages A311-A312 (April 2015) DOI: 10.1016/j.joca.2015.02.564 Copyright © 2015 Terms and Conditions

Figure 1. Trabecular thickness of TET mice under high fat & high cholesterol diet is significantly higher than the other three groups. Osteoarthritis and Cartilage 2015 23, A311-A312DOI: (10.1016/j.joca.2015.02.564) Copyright © 2015 Terms and Conditions

Figure 2. Bone surface to volume ratio of TET mice under high fat & high cholesterol diet is lower than the other three groups, indicating less bone resorption. Osteoarthritis and Cartilage 2015 23, A311-A312DOI: (10.1016/j.joca.2015.02.564) Copyright © 2015 Terms and Conditions

Figure 3. There bone volume fraction of subchondral bone in TET-mice is drastically increased upon high fat & high cholesterol diet. Osteoarthritis and Cartilage 2015 23, A311-A312DOI: (10.1016/j.joca.2015.02.564) Copyright © 2015 Terms and Conditions

Figure 4. TET mice fed with high fat & high cholesterol diet had more proteoglycan loss when compared. Osteoarthritis and Cartilage 2015 23, A311-A312DOI: (10.1016/j.joca.2015.02.564) Copyright © 2015 Terms and Conditions

Figure 5. TET mice fed with high fat & high cholesterol diet had more osteoclastic bone resoprtion activity. Osteoarthritis and Cartilage 2015 23, A311-A312DOI: (10.1016/j.joca.2015.02.564) Copyright © 2015 Terms and Conditions