Impact of Patient Characteristics and Anatomy on Results of Norwood Operation for Hypoplastic Left Heart Syndrome Bahaaldin Alsoufi, MD, Makoto Mori,

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Impact of Patient Characteristics and Anatomy on Results of Norwood Operation for Hypoplastic Left Heart Syndrome Bahaaldin Alsoufi, MD, Makoto Mori, BS, Scott Gillespie, MS, Brian Schlosser, BS, FASE, Timothy Slesnick, MD, Brian Kogon, MD, Dennis Kim, MD, PhD, Ritu Sachdeva, MBBS, Kirk Kanter, MD The Annals of Thoracic Surgery Volume 100, Issue 2, Pages 591-598 (August 2015) DOI: 10.1016/j.athoracsur.2015.03.106 Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Competing risks analysis of outcomes after Norwood operation in 219 neonates with hypoplastic left heart syndrome. All patients began alive at Norwood operation and thereafter could transition to one of two mutually exclusive outcomes: death/transplantation or Glenn operation. Solid lines represent parametric point estimates. Dashed lines enclose the 95% confidence interval. (a) Competing hazard functions for each outcome. (b) Proportion of neonates in each of the categories at any given time after Norwood operation. The Annals of Thoracic Surgery 2015 100, 591-598DOI: (10.1016/j.athoracsur.2015.03.106) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Competing risks analysis of outcomes after Glenn operation in 162 neonates with hypoplastic left heart syndrome. All patients began alive at the Glenn operation and thereafter could transition to one of two mutually exclusive outcomes: death/transplantation or Fontan procedure. Solid lines represent parametric point estimates. Dashed lines enclose the 95% confidence interval. (a) Competing hazard functions for each outcome. (b) Proportion of neonates in each of the categories at any given time after the Glenn operation. The Annals of Thoracic Surgery 2015 100, 591-598DOI: (10.1016/j.athoracsur.2015.03.106) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 (a) Time-dependent survival and (b) risk hazard of death over time after Norwood operation. Solid lines in the parametric model represent parametric point estimates. Dashed lines enclose the 95% confidence interval. Circles represent nonparametric estimates. The Annals of Thoracic Surgery 2015 100, 591-598DOI: (10.1016/j.athoracsur.2015.03.106) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Parametric model for survival after Norwood operation stratified by requirement for postoperative extracorporeal membrane oxygenation support. The Annals of Thoracic Surgery 2015 100, 591-598DOI: (10.1016/j.athoracsur.2015.03.106) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Parametric model for survival after Norwood operation stratified by genetic syndromes or major extracardiac anomalies. The Annals of Thoracic Surgery 2015 100, 591-598DOI: (10.1016/j.athoracsur.2015.03.106) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 6 Parametric model for survival after Norwood operation stratified by requirement for unplanned cardiac reoperation. The Annals of Thoracic Surgery 2015 100, 591-598DOI: (10.1016/j.athoracsur.2015.03.106) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 7 Parametric model for survival after Norwood operation stratified by source of pulmonary blood flow at the time of Norwood operation: modified Blalock-Taussig versus right ventricle to pulmonary artery shunt (Sano) shunt. The Annals of Thoracic Surgery 2015 100, 591-598DOI: (10.1016/j.athoracsur.2015.03.106) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 8 Parametric model for survival after Norwood operation stratified by premature birth equal or less than 36 weeks’ gestation. The Annals of Thoracic Surgery 2015 100, 591-598DOI: (10.1016/j.athoracsur.2015.03.106) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions