NCoR1 controls basal expression of T3-target genes.

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NCoR1 controls basal expression of T3-target genes. NCoR1 controls basal expression of T3-target genes. (A) The heat map depicts changes in gene expression (microarray) and H3K27 acetylation (CHIP-seq) caused by disruption/deletion of NCoR1. (A, 1) Up-regulated genes in livers of euthyroid or hypothyroid mice. (A, 2) Down-regulated genes in livers of euthyroid or hypothyroid mice. The yellow-to-red scale indicates a log2 fold change. Mice were fed a chow or a PTU/LID diet (n = 3). (B) The table displays the number of changed genes in control vs. NCoR1ΔID in the euthyroid (chow diet) or hypothyroid (PTU/LID diet) conditions, the number and percentage of genes that had associated H3K27ac ChIP peaks in control vs. NCoR1-KO mice, and the number and percentage of genes that showed overlap between the TRβ1 ChIP peak and H3K27ac within 100 kb of the TSS. Arturo Mendoza et al. PNAS 2017;114:40:E8458-E8467 ©2017 by National Academy of Sciences