Relationship between prechallenge AVA-induced TNA levels and probability of animal survival following lethal challenge with B. anthracis spores in rabbit.

Slides:

Advertisements

Similar presentations

Optimizing the Use of Anthrax Vaccine Workshop on the Biology of Anthrax, Cardiff, Wales 12 March, 2014 Thomas Waytes, MD, PhD V.P. Medical Affairs.

Advertisements

Vaccines and Related Biological Products Advisory Committee Meeting DMID/NIAID efforts that support the pathway to licensure for protective antigen-based.

CBER Perspective VRBPAC Meeting, November 16, 2010.

Pathway to Licensure for Protective Antigen-based Anthrax Vaccines for a Post-exposure Prophylaxis Indication Using the Animal Rule.

Math Graphing Linear Inequalities in Two Variables 1.

Cube Root Functions 6.3 – Day 2.

FMDV-specific IgG, IgG1, and IgG2 in sera of guinea pigs (n = 6/group) immunized on days 1 and 21 by intramuscular injection of FMDV antigens (type O)

by Michael J. Mina, C. Jessica E. Metcalf, Rik L. de Swart, A. D. M. E

Virus-specific serum antibody response of BALB/c mice to DNA prime followed by VRP boost. Virus-specific serum antibody response of BALB/c mice to DNA.

Protection from influenza virus challenge.

FMD VP1-specific IgG, IgG1, and IgG2 in sera of guinea pigs (n = 6/group) immunized on days 1 and 21 by intramuscular injection of FMDV antigens (type.

Detection of CSFV-specific antibodies in immunized/challenged pigs using blocking ELISA. Groups of pigs (n = 5) were inoculated with different doses of.

Virus-specific serum antibody response of BALB/c mice to DNA prime followed by VRP boost. Virus-specific serum antibody response of BALB/c mice to DNA.

DCs induce the proliferation of autologous T cells.

Immune response to vaccination with AVA in healthy human subjects (human immunogenicity study). Immune response to vaccination with AVA in healthy human.

Survival of BALB/c mice after HK/Syd challenge.

CCL19 levels are elevated in Lyme disease cases with PTLDS

Serum neutralizing antibody response of BALB/c mice to DNA prime followed by VRP boost. Serum neutralizing antibody response of BALB/c mice to DNA prime.

Survival and time to death of NZW rabbits following vaccination with AVA and subsequent lethal B. anthracis spore challenge (rabbit preexposure prophylaxis.

Tetramer staining performed to determine frequencies of epitope-specific T cells after clearance of HPV16 infection but prior to isolation of T-cell clones.

Survival of NZW rabbits following lethal B

Assessment of lymphocyte telomere length in a patient with dyskeratosis congenita. Assessment of lymphocyte telomere length in a patient with dyskeratosis.

Immune response to vaccination with AVA in NZW rabbits (rabbit preexposure prophylaxis study). Immune response to vaccination with AVA in NZW rabbits (rabbit.

Comparison of therapeutic efficacies of C12G6 and other bnAbs in mice

Antibody endpoint titers induced by PfCelTOS vaccines containing various adjuvant formulations with emulsion doses of 0.5% to 2% (vol/vol) oil, as measured.

Survival and time to death of cynomolgus macaques following vaccination with AVA and subsequent lethal B. anthracis spore challenge (NHP preexposure prophylaxis.

Longevity of mucosal and systemic antibody responses induced by pulmonary vaccination. Longevity of mucosal and systemic antibody responses induced by.

Increased proinflammatory cytokine production is dependent on both the training interval and the resting time. Increased proinflammatory cytokine production.

Fig. 3. Effect of substrate orientation on growth rate for bottom-dwelling tadpoles with similar oral configuration. Effect of substrate orientation on.

Contribution of individual serovars within serogroups isolated in the United States in Contribution of individual serovars within serogroups isolated.

Pulmonary vaccination induces a long-term immune memory response to antigen challenge. Pulmonary vaccination induces a long-term immune memory response.

Anti-inflammatory cytokine production is increased in trained monocytes. Anti-inflammatory cytokine production is increased in trained monocytes. (A) IL-10.

Dose–response curve for the rate ratio (solid line) and 95% CIs (dashed lines) of pneumonia as a function of inhaled corticosteroid dose in μg (measured.

Immune response to vaccination with AVA in cynomolgus macaques (NHP preexposure prophylaxis study). Immune response to vaccination with AVA in cynomolgus.

Reproducibility of LPA results for cryopreserved PBMC after variable periods of storage in liquid nitrogen. Reproducibility of LPA results for cryopreserved.

Viability and viable cell recovery of cryopreserved PBMC after variable periods of storage in liquid nitrogen. Viability and viable cell recovery of cryopreserved.

Trained immunity induction of glycolysis.

Intranasal immunization of mice with S

Antibody titers against surface antigens of B

Trained immunity effects on cell morphology and numbers.

Results from human serum samples determined using the five-antigen multiplex assay. Results from human serum samples determined using the five-antigen.

Scattergrams showing IgG- and IgA-specific OD490 values measured with the Campylobacter-specific P18/P39 ELISA in sera from healthy controls and from GBS.

RTA-specific serum IgG antibody titers and TNA in mice immunized with RiVax or RVEc. RTA-specific serum IgG titers after the second (A) or third (B) immunizations.

Identifying risk factors: Challenges of separating signal from noise

Dilution of anti-C6 monoclonal antibody shows the broader linear range of the Multiplex assay in comparison to standard ELISA. Shown is the dilution of.

Reproducibility of CD4+ and CD8+ T-cell enumeration with cryopreserved PBMC after variable periods of storage in liquid nitrogen. Reproducibility of CD4+

Reproducibility of the enumeration of the percentages of CD4+ CD45RA+ CD95−, CD4+ CD38+, and CD8+ CD38+ in cryopreserved PBMC after variable periods of.

Antibody titers against surface antigens of M

Relation between the total white blood count and the absolute lymphocyte count prior to the first vaccination and the response to vaccination. Relation.

Identification of the recombinant structural proteins expressed in recombinant baculovirus-infected Sf9 cells by immunofluorescence assay with rabbit anti-FMDV.

B- and T-cell activity induced by immunization.

Induction of OVA-specific CTLs by DCs

Tumor protection induced by therapeutic PLG vaccination in combination with blockade antibodies. Tumor protection induced by therapeutic PLG vaccination.

Individual values for the tTg-IgA Celikey assay (A), the tTG-IgG Celikey assay (B), the DGP (IgA+IgG) screen (C), and the tTG-IgA Immulite 2000 assay (D),

TNA associated with FD3-specific Abs.

Group-averaged IL-10 levels (in pg/ml) from the Luminex assay for control, CFS with FM, and CFS without FM groups. Group-averaged IL-10 levels (in pg/ml)

Diethylamine-based measles avidity assay.

Long-lived antibody-secreting cells in the bone marrow, induced by PfCelTOS vaccines containing various adjuvant formulations with emulsion doses of 0.02%

Long-lived antibody-secreting cells in the bone marrow, induced by PfCelTOS vaccines containing various adjuvant formulations with emulsion doses of 0.5%

Fig. 1 ZMAb improves survival of EBOV-challenged NHPs

Time to culling for mastitis among J5 vaccinates and controls

Anti-PT IgG results from 227 patients with coughs of unknown etiology who reported the severity of cough on a scale from 0 to 10. Anti-PT IgG results from.

Lkt antibody titers of vaccinated and control groups of BHS

Schematic presentation of the major domains of Alps, the signal peptide (S), the N-terminal region (N), the repeat region (R), and the C-terminal region.

Relationship between darunavir IQ and the probability of virologic success (HIV-1 RNA

Time to culling for all reasons among J5 vaccinates and controls

IgA and IgG antibodies reactive to TT, alpha-toxin, and BSA in two groups of chickens 2 weeks after oral gavage with probiotics or with PBS. The two groups.

Distribution of responses to vaccine antigens in the culture-positive individual group and the control group. Distribution of responses to vaccine antigens.

Mean reciprocal IFA titer results for serum samples from experimentally vaccinated animals. Mean reciprocal IFA titer results for serum samples from experimentally.

Variability between laboratories in titer estimations (expressed as GCV on the y axis) tends to be higher for samples in low measurement ranges and to.

Presentation transcript:

Relationship between prechallenge AVA-induced TNA levels and probability of animal survival following lethal challenge with B. anthracis spores in rabbit (A) and NHP (B) preexposure prophylaxis studies. Relationship between prechallenge AVA-induced TNA levels and probability of animal survival following lethal challenge with B. anthracis spores in rabbit (A) and NHP (B) preexposure prophylaxis studies. Logistic regression models were fitted to the survival curve and either day 69 TNA NF50 levels in rabbits (A) (n = 96) or day 70 TNA NF50 levels in NHPs (B) (n = 39) in order to assess antibody level immediately prior to anthrax challenge as a predictor of survival in the vaccinated animals. Individual values below the LOQ were replaced with the LOQ value (0.086 for rabbit samples and 0.105 for NHP samples). The graphs represent the logistic curves fitted to the data (solid lines) and 95% confidence intervals (dashed lines). Individual animal data points are represented by open-circle symbols (○); survival = 1; death = 0. Boris Ionin et al. Clin. Vaccine Immunol. 2013; doi:10.1128/CVI.00099-13