The Lymphatic Vasculature: Its Role in Adipose Metabolism and Obesity

Slides:

Advertisements

Similar presentations

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Advertisements

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.

PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors Joan Sanchez-Gurmaches, Chien-Min.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

The Current Role of Operative Venous Thrombectomy in Deep Vein Thrombosis Anthony J. Comerota Seminars in Vascular Surgery Volume 25, Issue 1, Pages 2-12.

Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages

Jeffrey T Wigle, Guillermo Oliver Cell

The ART of Lowering Ceramides

Ectopic fat and cardiometabolic and vascular risk

Volume 14, Issue 2, Pages (August 2011)

Immunological Goings-on in Visceral Adipose Tissue

Focus on lymphangiogenesis in tumor metastasis

Diabetes Risk Begins In Utero

Does Hypothalamic Inflammation Cause Obesity?

Specialized Perinodal Fat Fuels and Fashions Immunity

In and Out: Adipose Tissue Lipid Turnover in Obesity and Dyslipidemia

Omega 3 Fatty Acids and GPR120

Mrap2: An Accessory Protein Linked to Obesity

Volume 16, Issue 6, Pages (June 2015)

Volume 12, Issue 5, Pages (November 2010)

Volume 23, Issue 2, Pages (February 2016)

Jeffrey T Wigle, Guillermo Oliver Cell

Fibrosis and Adipose Tissue Dysfunction

Fingered for a Fat Fate Cell Metabolism

Macrophage Metabolism Shapes Angiogenesis in Tumors

Gal3 Links Inflammation and Insulin Resistance

Volume 24, Issue 1, Pages (July 2016)

Come on BAIBA Light My Fire

Immunological Goings-on in Visceral Adipose Tissue

Is Predisposition to NAFLD and Obesity Communicable?

VEGF-B Improves Metabolic Health through Vascular Pruning of Fat

Volume 20, Issue 6, Pages (December 2014)

Thiazolidinediones Regulate Adipose Lineage Dynamics

Irisin, Turning Up the Heat

Why We Should Put Clothes on Mice

White, Brown, and Beige; Type 2 Immunity Gets Hot

IL-6 Muscles In on the Gut and Pancreas to Enhance Insulin Secretion

Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

The Infectious Cause of the Chronic Effect

Focus on lymphangiogenesis in tumor metastasis

Volume 17, Issue 5, Pages (May 2013)

NRG4: An Endocrine Link between Brown Adipose Tissue and Liver

VEGF-B Improves Metabolic Health through Vascular Pruning of Fat

Volume 25, Issue 2, (February 2017)

Andrea Frontini, Saverio Cinti Cell Metabolism

Volume 17, Issue 5, Pages (May 2013)

Volume 15, Issue 2, Pages (February 2012)

In and Out: Adipose Tissue Lipid Turnover in Obesity and Dyslipidemia

Jan Nedergaard, Barbara Cannon Cell Metabolism

Weighing in on Adipocyte Precursors

Volume 1, Issue 4, Pages (April 2005)

Volume 24, Issue 20, Pages R988-R993 (October 2014)

A New Role for Glia in Leptin Action and Energy Balance

Before They Were Fat: Adipocyte Progenitors

Brown and Beige Fat: Physiological Roles beyond Heat Generation

Exercise Controls Non-Coding RNAs

Volume 14, Issue 2, Pages (August 2011)

Lymphatic Vessels at the Heart of the Matter

Linking DNA Damage, NAD+/SIRT1, and Aging

Adipose Dendritic Cells Come Out of Hiding

Ann Marie Schmidt, Kathryn J. Moore Cell Metabolism

Volume 15, Issue 2, Pages (February 2012)

On Bone-Forming Cells and Blood Vessels in Bone Development

Targeting Fat to Prevent Diabetes

Rejuvenation: It’s in Our Blood

Estrogens and Obesity: Is It All in Our Heads?

Presentation transcript:

The Lymphatic Vasculature: Its Role in Adipose Metabolism and Obesity Noelia Escobedo, Guillermo Oliver Cell Metabolism Volume 26, Issue 4, Pages 598-609 (October 2017) DOI: 10.1016/j.cmet.2017.07.020 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Lymphatic Vascular Defects Contribute to Adult-Onset Obesity In Prox1+/− mice, compromised lymphatic vascular integrity causes subtle leakage of lymph. FFA-containing lymph accumulates in the nearby tissues, particularly in the visceral area, where it induces de novo differentiation of fat cell precursors, fat cell hypertrophy, and eventually adipocyte proliferation. With age, Prox1+/− mice became progressively obese. Cell Metabolism 2017 26, 598-609DOI: (10.1016/j.cmet.2017.07.020) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 2 Presence of Lymphatic Vessels in Fat Depots of Adult Mice Visceral fat depots were dissected and subject to whole-mount immunostaining with antibodies against lymphatic endothelial cells (Lyve1 and Prox1) and adipocytes (Perilipin). Lymphatic vessels are seen deep inside the WAT and nearby blood vessels (data not shown). LV, lymphatic vessel. Scale bar, 30 μM. Cell Metabolism 2017 26, 598-609DOI: (10.1016/j.cmet.2017.07.020) Copyright © 2017 Elsevier Inc. Terms and Conditions