Continuous warm versus intermittent cold cardioplegic infusion: A comparison of energy metabolism, sodium-potassium adenosine triphosphatase activity,

Slides:

Advertisements

Similar presentations

The additional hospital costs generated in the management of complications of pacemaker and defibrillator implantations T.Bruce Ferguson, MD, Candice Lilley.

Advertisements

Influence of normothermic systemic perfusion during coronary artery bypass operations: A randomized prospective study Inderpaul Birdi, FRCS, Idris Regragui,

Manuel J. Antunes, MD, PhD, DSc

Myocardial protection with oxygenated esmolol cardioplegia during prolonged normothermic ischemia in the rat Ryuzo Bessho, MD, PhD, David J. Chambers,

Early reperfusion with warm, polarizing adenosine–lidocaine cardioplegia improves functional recovery after 6 hours of cold static storage Donna M. Rudd,

Functional evaluation of human donation after cardiac death donor hearts using a continuous isolated myocardial perfusion technique: Potential for expansion.

Prolonged donor heart preservation with pinacidil: The role of mitochondria and the mitochondrial adenosine triphosphate–sensitive potassium channel

Hot shot induction and reperfusion with a specific blocker of the es-ENT1 nucleoside transporter before and after hypothermic cardioplegia abolishes myocardial.

Delivery of a nonpotassium modified maintenance solution to enhance myocardial protection in stressed neonatal hearts: A new approach Michael T. Kronon,

Nitric oxide–generating β-adrenergic blocker nipradilol preserves postischemic cardiac function Hitoshi Horimoto, MD, Adam E Saltman, MD, PhD, Glenn.

Terje K. Steigen, MD, Ellen Aasum, MS, Truls Myrmel, MD, PhDa, Terje S

Influence of oxygen in inflation gas during lung ischemia on ischemia-reperfusion injury Atsushi Watanabe, MD, Nobuyoshi Kawaharada, MD, Katsuyuki Kusajima,

The role of cardioplegia induction temperature and amino acid enrichment in neonatal myocardial protection Michael T Kronon, MD, Bradley S Allen, MD,

Aprotinin preserves myocardial biochemical function during cold storage through suppression of tumor necrosis factor David A. Bull, MD, Rafe C. Connors,

Superior protection in orthotopic rat lung transplantation with cyclic adenosine monophosphate and nitroglycerin–containing preservation solution Koichi.

Akihiko Ohkado, MD, Hung Cao-Danh, PhD, K. Eric Sommers, MD, Pedro J

Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: Phosphorus 31—nuclear magnetic resonance measurements.

Centers for Disease Control “increased-risk” organ donor: Not so risky? Francis D. Pagani, MD, PhD The Journal of Thoracic and Cardiovascular Surgery

Blood cardioplegia enhanced with nitric oxide donor SPM-5185 counteracts postischemic endothelial and ventricular dysfunction Katsuhiko Nakanishi, MD,

Victor van Berkel, MD, PhD

Long-term myocardial preservation: effects of hyperkalemia, sodium channel, and NA+/K+/2CL- cotransport inhibition on extracellular potassium accumulation.

Shigeyuki Sasaki, MD, PhD (by invitation), James D

Philippe Menasché, MD, PhD

Intracellular free calcium accumulation in ferret vascular smooth muscle during crystalloid and blood cardioplegic infusions Motohisa Tofukuji, MD, PhDa,

The lord of the rings Antonio Miceli, MD, PhD

Effects of cardioplegia on vascular function and the “no-reflow" phenomenon after ischemia and reperfusion: Studies in the isolated blood-perfused rat.

Intermittent aortic crossclamping prevents cumulative adenosine triphosphate depletion, ventricular fibrillation, and dysfunction (stunning): Is it preconditioning?

Myocardial metabolic changes during pediatric cardiac surgery: A randomized study of 3 cardioplegic techniques P. Modi, FRCS, M.-S Suleiman, PhD, B Reeves,

Effect of esophageal distention on pressure and electromyographic activity of the pharyngoesophageal sphincter, with identification of the esophagopharyngeal.

Editorial: The core of leadership

The variability of the mitral valve anatomy and terminology

Ganghong Tian, MD, PhDa, Bo Xiang, DDSa, Keith W

Ischemic intervals during warm blood cardioplegia in the canine heart evaluated by phosphorus 31-magnetic resonance spectroscopy Nilto Carias de Oliveira,

Myocardial protection in normal and hypoxically stressed neonatal hearts: The superiority of hypocalcemic versus normocalcemic blood cardioplegia Kirk.

Support Your Specialty

Innovation and science: The future of valve design

Intermediate-Term Outcome Of Mitral Reconstruction In Cardiomyopathy

Elucidation of a tripartite mechanism underlying the improvement in cardiac tolerance to ischemia by coenzyme Q10 pretreatment Juan A. Crestanello, MD.

Cardioplegia and vascular injury

Improved myocardial protection in the failing heart by selective endothelin-A receptor blockade Karola Trescher, MD, Michael Bauer, MD, Wolfgang Dietl,

Experimental study of intermittent crossclamping with fibrillation and myocardial protection: Reduced injury from shorter cumulative ischemia or intrinsic.

Metabolic and hemodynamic effects of intravenous glutamate infusion early after coronary operations Rolf Svedjeholm, MD, PhDa, Ingemar Vanhanen, MDa,

Aging reduces postischemic recovery of coronary endothelial function

Reply Journal of Vascular Surgery

Michael Kronon, MD. , Kirk S. Bolling, MD, Bradley S

Left atrial pressure measurement in a rat is currently impossible due to size limitations of balloon occlusion catheter Filip Konecny, MSc, DVM, PhD

Shinya Murakami, MD. , Emile A. Bacha, MD

Attachment disorder in thoracoabdominal surgery

Patient recovery after intermittent disc escape and spontaneous recession of a mechanical heart valve Francis Robicsek, MD, PhD, Joseph W. Cook, MD

Increase in size of the pulmonary autograft after the ross operation in children: Growth or dilation? Laszlo Solymar, MD, PhD, Göran Südow, MD, Daniel.

Ara K. Pridjian, MD, Edward L. Bove, MD, Flavian M. Lupinetti, MD

Manuel J. Antunes, MD, PhD, DSc

Ischemic preconditioning does not acutely improve load-insensitive parameters of contractility in in vivo stunned porcine myocardium M.Salik Jahania,

Improvement in functional recovery of the isolated guinea pig heart after hyperkalemic reperfusion with adenosine Helmut Habazettl, MD, Barbara W. Palmisano,

Adenosine-enhanced ischemic preconditioning provides myocardial protection equal to that of cold blood cardioplegia James D McCully, PhD, Masahisa Uematsu,

Simultaneous Antegrade And Retrograde Delivery Of Continuous Warm Blood Cardioplegia After Global Ischemia Anders B. Ericsson, MD, Shigeto Takeshima,

The Journal of Thoracic and Cardiovascular Surgery

Discussion The Journal of Thoracic and Cardiovascular Surgery

Intermittent warm blood cardioplegia in the surgical treatment of congenital heart disease: Clinical experience with 1400 cases Yves Durandy, MD, Sylvie.

The future of cardiac surgery training: A survival guide

The continuing challenge of congenital heart disease in China

Michael T. Kronon, MD, Bradley S

L-arginine, prostaglandin, and white cell filtration equally improve myocardial protection in stressed neonatal hearts Michael T. Kronon, MD, Bradley.

Natriuresis after cardiopulmonary bypass: Relationship to urodilatin, atrial natriuretic factor, antidiuretic hormone, and aldosterone Jens Sehested,

Early effects of hypothyroidism on the contractile function of the rat heart and its tolerance to hypothermic ischemia Manuel Galiñanes, MD, PhD, Ryszard.

“The more things change…”: The challenges ahead

Insulin-induced improvement of postischemic recovery is abolished by inhibition of protein kinase C in rat heart Ulrich Fischer-Rasokat, BS, Torsten.

Loss of endothelium-dependent vasodilatation and nitric oxide release after myocardial protection with University of Wisconsin solution Jeffrey M. Pearl,

Did you like Terminator 3 better than Terminator 2

Adenosine and lidocaine: a new concept in nondepolarizing surgical myocardial arrest, protection, and preservation Geoffrey P. Dobson, PhD, Michael W.

Presentation transcript:

Continuous warm versus intermittent cold cardioplegic infusion: A comparison of energy metabolism, sodium-potassium adenosine triphosphatase activity, and postischemic functional recovery in the blood-perfused rat heart Yumin Qiu, MD, PhD, Manuel Galiñanes, MD, PhD, Peter S. Haddock, PhD, David J. Hearse, DSc The Journal of Thoracic and Cardiovascular Surgery Volume 112, Issue 3, Pages 797-805 (September 1996) DOI: 10.1016/S0022-5223(96)70067-3 Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Experimental protocol. Control hearts (n = 6) were aerobically perfused with blood from support rat. Hearts (n = 12 per group) in continuous warm blood cardioplegic, continuous warm crystalloid cardioplegic, and intermittent cold cardioplegic groups were preserved for 3 hours with one of these three cardioplegic interventions. At the end of this period, hearts (n = 6 per group) were taken for analysis of tissue Na+/K+-ATPase activity. Remaining hearts (n = 6 per group) were perfused aerobically with blood for additional 50 minutes and contractile function and high-energy phosphate levels were assessed at the end of this period. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 797-805DOI: (10.1016/S0022-5223(96)70067-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Systolic (A) and diastolic (B) functions at the end of 50 minutes of aerobic blood perfusion in control hearts (n = 6) and hearts (n = 6 per group) protected with continuous warm blood cardioplegic infusion, continuous warm crystalloid cardioplegic infusion, and intermittent cold cardioplegic infusion. Data presented as mean ± SEM. Asterisk indicates p < 0.05 compared with intermittent cold cardioplegic and continuous warm crystalloid cardioplegic groups; dagger indicates p < 0.05 compared with all other groups; hatch mark indicates p < 0.05 compared with intermittent cold cardioplegic and control groups. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 797-805DOI: (10.1016/S0022-5223(96)70067-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Systolic (A) and diastolic (B) functions at the end of 50 minutes of aerobic blood perfusion in control hearts (n = 6) and hearts (n = 6 per group) protected with continuous warm blood cardioplegic infusion, continuous warm crystalloid cardioplegic infusion, and intermittent cold cardioplegic infusion. Data presented as mean ± SEM. Asterisk indicates p < 0.05 compared with intermittent cold cardioplegic and continuous warm crystalloid cardioplegic groups; dagger indicates p < 0.05 compared with all other groups; hatch mark indicates p < 0.05 compared with intermittent cold cardioplegic and control groups. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 797-805DOI: (10.1016/S0022-5223(96)70067-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 3 Perfusion pressure during 50 minutes of aerobic blood perfusion in control hearts (n = 6) and hearts (n = 6 per group) protected with continuous warm blood cardioplegic infusion, continuous warm crystalloid cardioplegic infusion, and intermittent cold cardioplegic infusion. Data presented as mean ± SEM. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 797-805DOI: (10.1016/S0022-5223(96)70067-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 4 Tissue ATP (A) and CP (B) levels at end of 50 minutes of aerobic blood perfusion in control hearts (n = 6) and hearts (n = 6 per group) protected with continuous warm blood cardioplegic infusion, continuous warm crystalloid cardioplegic infusion, and intermittent cold cardioplegic infusion. Data presented as mean ± SEM. Asterisk indicates p < 0.05 compared with control hearts. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 797-805DOI: (10.1016/S0022-5223(96)70067-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 4 Tissue ATP (A) and CP (B) levels at end of 50 minutes of aerobic blood perfusion in control hearts (n = 6) and hearts (n = 6 per group) protected with continuous warm blood cardioplegic infusion, continuous warm crystalloid cardioplegic infusion, and intermittent cold cardioplegic infusion. Data presented as mean ± SEM. Asterisk indicates p < 0.05 compared with control hearts. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 797-805DOI: (10.1016/S0022-5223(96)70067-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 5 Tissue Na+/K+-ATPase activity in fresh control hearts (n = 6) and hearts (n = 6 per group) at the end of 3 hours of protection with continuous warm blood cardioplegic infusion, continuous warm crystalloid cardioplegic infusion, and intermittent cold cardioplegic infusion. Data presented as mean ± SEM. Asterisk indicates p < 0.05 compared with all other groups. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 797-805DOI: (10.1016/S0022-5223(96)70067-3) Copyright © 1996 Mosby, Inc. Terms and Conditions