Volume 56, Issue 5, Pages (November 1999)

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Volume 56, Issue 5, Pages 1779-1787 (November 1999) Brief periods of hyperphagia cause renal injury in the obese Zucker rat Matthew D. Gades, Harry van Goor, George A. Kaysen, Dr, Patricia R. Johnson, Barbara A. Horwitz, Judith S. Stern Kidney International Volume 56, Issue 5, Pages 1779-1787 (November 1999) DOI: 10.1046/j.1523-1755.1999.00731.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 Average body weights for ad libitum-fed obese (•; AL-obese) and obese pair-fed to lean up to 21 weeks of age and then ad libitum-fed to 57 weeks (⋄; PF.AL-obese) female Zucker rats. Data are mean ± SE. Kidney International 1999 56, 1779-1787DOI: (10.1046/j.1523-1755.1999.00731.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 Average daily food intake for ad libitum-fed obese (•; AL-obese) and obese pair-fed to lean up to 21 weeks of age and then ad libitum-fed to 57 weeks (⋄; PF.AL-obese) female Zucker rats. Data are mean ± SE. Kidney International 1999 56, 1779-1787DOI: (10.1046/j.1523-1755.1999.00731.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 3 Average 24-hour urinary albumin excretion (UAE) for ad libitum-fed obese (•; AL-obese) and obese pair-fed to lean up to 21 weeks of age and then ad libitum-fed to 57 weeks (⋄; PF.AL-obese) female Zucker rats. Data are mean ± SE. *P < 0.05 for AL vs. PF-/PF.AL-obese. Kidney International 1999 56, 1779-1787DOI: (10.1046/j.1523-1755.1999.00731.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 4 Range, and 25th, 50th, and 75th percentiles of 24-hour urinary albumin excretion in ad libitum-fed obese (AL-obese, N = 15) and obese pair-fed compared to lean up to 21 weeks of age and then ad libitum-fed to 57 weeks (PF.AL-obese, N = 15), ad libitum-fed lean (AL-lean, N = 7) female Zucker rats. Groups with different letters differ significantly (P < 0.05). Data are mean ± SE. Kidney International 1999 56, 1779-1787DOI: (10.1046/j.1523-1755.1999.00731.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 5 Average fasting plasma triglycerides for ad libitum-fed obese (•; AL-obese) and obese pair-fed to lean up to 21 weeks of age and then ad libitum-fed to 57 weeks (⋄; PF.AL-obese) female Zucker rats. Data are mean ± SE. *P < 0.05 for AL vs. PF-/PF.AL-obese. Kidney International 1999 56, 1779-1787DOI: (10.1046/j.1523-1755.1999.00731.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 6 Range, and 25th, 50th, and 75th percentiles of fasting plasma triglycerides in ad libitum-fed obese (AL-obese, N = 15) and obese pair-fed to lean up to 21 weeks of age and then ad libitum-fed to 57 weeks (PF.AL-obese, N = 15), ad libitum-fed lean (AL-lean, N = 7) female Zucker rats. Groups with different letters differ significantly (P < 0.05). Data are mean ± SE. Kidney International 1999 56, 1779-1787DOI: (10.1046/j.1523-1755.1999.00731.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 7 Average fasting cholesterol for ad libitum-fed obese (•; AL-obese), and obese pair-fed to lean up to 21 weeks of age and then ad libitum-fed to 57 weeks (⋄; PF.AL-obese) female Zucker rats. Data are mean ± SE. *P < 0.05 for AL vs. PF-/PF.AL-obese. Kidney International 1999 56, 1779-1787DOI: (10.1046/j.1523-1755.1999.00731.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 8 Range, and 25th, 50th, and 75th percentiles of fasting plasma cholesterol in ad libitum-fed obese (AL-obese, N = 15) and obese pair-fed to lean up to 21 weeks of age and then ad libitum-fed to 57 weeks (PF.AL-obese, N = 15), ad libitum-fed lean (AL-lean, N = 7) female Zucker rats. Groups with different letters differ significantly (P < 0.05). Data are mean ± SE. Kidney International 1999 56, 1779-1787DOI: (10.1046/j.1523-1755.1999.00731.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 9 Individual values for plasma albumin and renal albumin clearance values at 29 weeks of age in ad libitum-fed obese (•; AL-obese), and obese pair-fed to lean up to 21 weeks of age and then ad libitum-fed to 57 weeks (⋄; PF.AL-obese) female Zucker rats. Kidney International 1999 56, 1779-1787DOI: (10.1046/j.1523-1755.1999.00731.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 10 Representative glomeruli from (A and B) in ad libitum-fed obese (AL-obese; C) pair-fed obese (PF-obese), (D) ad libitum–fed lean (AL-lean) Zucker rats. Oil Red O staining on representative glomeruli from (E) pair-fed obese (PF-obese) and (F) ad libitum-fed obese (AL-obese) female Zucker rats at 21 weeks of age. Kidney International 1999 56, 1779-1787DOI: (10.1046/j.1523-1755.1999.00731.x) Copyright © 1999 International Society of Nephrology Terms and Conditions