The quest for autoreactive antibodies in nasal polyps

Slides:

Advertisements

Similar presentations

Anju T. Peters, MD, Atsushi Kato, PhD, Ning Zhang, PhD, David B

Advertisements

Dose-time-response relationship in peanut allergy using a human model of passive cutaneous anaphylaxis Anja P. Mose, MD, Charlotte G. Mortz, MD, PhD,

Kuan-Wei Chen, PhD, Katharina Blatt, MSc, Wayne R

Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3 Feng Lan, MD, Nan Zhang,

Chlamydophila (Chlamydia) pneumoniae serology and asthma in adults: A longitudinal analysis Rafael Pasternack, MD, PhD, Heini Huhtala, MSc, Jussi Karjalainen,

Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3 Feng Lan, MD, Nan Zhang,

Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps Bruce K. Tan, MD, Quan-Zhen Li, PhD, Lydia.

Jay A. Lieberman, MD, Faith R. Huang, MD, Hugh A

Anju T. Peters, MD, Atsushi Kato, PhD, Ning Zhang, PhD, David B

Atopic dermatitis: Age and race do matter!

Extracellular eosinophilic traps in association with Staphylococcus aureus at the site of epithelial barrier defects in patients with severe airway inflammation

Skin test diagnosis of grass pollen allergy with a recombinant hybrid molecule Carine Metz-Favre, MD, Birgit Linhart, PhD, Margarete Focke-Tejkl, PhD,

Oral steroids and doxycycline: Two different approaches to treat nasal polyps Thibaut Van Zele, MD, PhD, Philippe Gevaert, MD, PhD, Gabriele Holtappels,

Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study John M. Brehm, MD, MPH, Brooke Schuemann, BS,

Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD

Is 9 more than 2 also in allergic airway inflammation?

An Infant with Atopic Dermatitis and Itching After Ingestion of Milk

Half-life of IgE in serum and skin: Consequences for anti-IgE therapy in patients with allergic disease Monica G. Lawrence, MD, Judith A. Woodfolk, MBChB,

Mepolizumab, a humanized anti–IL-5 mAb, as a treatment option for severe nasal polyposis Philippe Gevaert, MD, PhD, Nicholas Van Bruaene, MD, Tom Cattaert,

T-cell regulation in chronic paranasal sinus disease

In vivo allergenic activity of a hypoallergenic mutant of the major fish allergen Cyp c 1 evaluated by means of skin testing Nikolaos Douladiris, MD,

Toll-like receptor 9 suppression in plasmacytoid dendritic cells after IgE-dependent activation is mediated by autocrine TNF-α John T. Schroeder, PhD,

Role of p63/p73 in epithelial remodeling and their response to steroid treatment in nasal polyposis Chun Wei Li, PhD, Li Shi, MD, Ke Ke Zhang, MD, Tian.

Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps Sarah Peterson, MD, Julie A. Poposki, MS, Deepti.

RAGE processing in chronic airway conditions: Involvement of Staphylococcus aureus and ECP Koen Van Crombruggen, PhD, Gabriele Holtappels, Natalie De.

Expression of FcɛRI on dendritic cell subsets in peripheral blood of patients with atopic dermatitis and allergic asthma Inge M.J. Beeren, MSc, Marjolein.

William J. Calhoun, MD, Tmirah Haselkorn, PhD, Dave P

David D. Tieu, MD, Anju T. Peters, MD, Roderick T

TGF-β signaling and collagen deposition in chronic rhinosinusitis

Serum tryptase levels in atopic and nonatopic children

Prathap Pillai, MD, Cailong Fang, PhD, Yih-Chih Chan, PhD, Mohamed H

Respiratory sensitization of a worker to the warehouse beetle Trogoderma variabile: An index case report Jonathan A. Bernstein, MD, Marjorie S. Morgan,

Thymic stromal lymphopoietin activity is increased in nasal polyps of patients with chronic rhinosinusitis Deepti R. Nagarkar, PhD, Julie A. Poposki,

Expression of the cysteinyl leukotriene receptors cysLT1 and cysLT2 in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis Chris Corrigan,

Nasal mucus proteomic changes reflect altered immune responses and epithelial permeability in patients with allergic rhinitis Peter Valentin Tomazic,

Kerstin Bauermeister, MSc, Barbara K

Individual IL-3 priming is crucial for consistent in vitro activation of donor basophils in patients with chronic urticaria Thomas Gentinetta, MSc, Tatjana.

Allergen-specific immunotherapy with recombinant grass pollen allergens Marek Jutel, MD, Lothar Jaeger, MD, Roland Suck, PhD, Hanns Meyer, Dipl Math,

Glandular mast cells with distinct phenotype are highly elevated in chronic rhinosinusitis with nasal polyps Tetsuji Takabayashi, MD, Atsushi Kato, PhD,

Kuan-Wei Chen, PhD, Katharina Blatt, MSc, Wayne R

Dose-time-response relationship in peanut allergy using a human model of passive cutaneous anaphylaxis Anja P. Mose, MD, Charlotte G. Mortz, MD, PhD,

Casein-related anaphylaxis after use of an Everlast kickboxing glove

Different IgE recognition of mite allergen components in asthmatic and nonasthmatic children Yvonne Resch, MSc, Sven Michel, MSc, Michael Kabesch, MD,

Serum autoreactivity predicts time to response to omalizumab therapy in chronic spontaneous urticaria Janine Gericke, PhD, Martin Metz, MD, Tatevik Ohanyan,

Autophagy: Nobel Prize 2016 and allergy and asthma research

New pathways for itching in patients with atopic dermatitis?

Sara Paveglio, PhD, MS, Erin Bennett, MS, Kelly L. Hawley, PhD, Adam P

α-Purothionin, a new wheat allergen associated with severe allergy

Recombinant allergen-based IgE testing to distinguish bee and wasp allergy Irene Mittermann, PhD, Mihaela Zidarn, MD, Mira Silar, PhD, Zora Markovic-Housley,

Biology of nasal polyposis

Reply Journal of Allergy and Clinical Immunology

Does “autoreactivity” play a role in atopic dermatitis?

Expression of chemokines and chemokine receptors in lesional and nonlesional upper skin of patients with atopic dermatitis Eva Gros, MSc, Caroline Bussmann,

Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps Joke Patou, MD, Philippe Gevaert, MD, PhD, Thibaut.

Biju Thomas, MD, Robert Anthony Hirst, PhD, Mina H

Reply Journal of Allergy and Clinical Immunology

Systemic and localized seminal plasma hypersensitivity patients exhibit divergent immunologic characteristics Debajyoti Ghosh, PhD, Jonathan A. Bernstein,

Macrolide antibiotics and asthma treatment

Asthma: The past, future, environment, and costs

Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother Sabine Flicker, PhD, Katharina Marth, MD, Heinz.

Bleomycin hydrolase downregulation in lesional skin of adult atopic dermatitis patients is independent of FLG gene mutations Laurence Pellerin, PhD,

Mite allergen–specific IgE is detectable in bronchial secretions of patients with nonatopic asthma and correlates with mucosal expression of periostin

IL-31 is associated with cutaneous lymphocyte antigen–positive skin homing T cells in patients with atopic dermatitis Janine Bilsborough, PhD, Donald.

Carrier-bound, nonallergenic Ole e 1 peptides for vaccination against olive pollen allergy Teresa E. Twaroch, MSc, Margit Focke, PhD, Vera Civaj, Milena.

Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma Philippe Gevaert, MD, PhD, Lien Calus, MD, Thibaut Van Zele,

Natural history of cow’s milk allergy

Eosinophil progenitor levels are increased in patients with active pediatric eosinophilic esophagitis David W. Morris, MD, Emily M. Stucke, BA, Lisa.

Carl Hamsten, MSc, PhD, Thi Anh T

Mast cell–associated alveolar inflammation in patients with atopic uncontrolled asthma Cecilia K. Andersson, PhD, Anders Bergqvist, MSc, Michiko Mori,

Increased immune reactivity to central nervous system–derived naturally presented peptides in patients with active multiple sclerosis Christine Riedhammer,

Presentation transcript:

The quest for autoreactive antibodies in nasal polyps Els De Schryver, MD, Lien Calus, MD, PhD, Henryk Bonte, MD, De Ruyck Natalie, MD, Hannah Gould, PhD, Erin Donovan, PhD, Dirk Elewaut, MD, PhD, Rudolf Valenta, MD, Irene Mittermann, PhD, Jan Gutermuth, MD, Tanja Seher, PhD, MD, Robert P. Schleimer, PhD, Bruce K. Tan, MD, MS, Lara Derycke, PhD, Thibaut Van Zele, MD, PhD, Claus Bachert, MD, PhD, Philippe Gevaert, MD, PhD Journal of Allergy and Clinical Immunology Volume 138, Issue 3, Pages 893-895.e5 (September 2016) DOI: 10.1016/j.jaci.2016.03.040 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 The detection of local and serum anti-dsDNA IgG. Data are expressed in Box-Whisker plots presenting the results of local and systemic anti-dsDNA IgG in patients with nasal polyps and healthy subjects. Significance (P) values after Mann-Whitney U test are represented by * when P < .05. Journal of Allergy and Clinical Immunology 2016 138, 893-895.e5DOI: (10.1016/j.jaci.2016.03.040) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 The detection of autoreactive IgE to the human epithelial cell line A431 (A), of local anti-IgE IgG (B) and of autoreactive IgE to skin and lung epithelium (C). A, Positive (atopic dermatitis [AD]) and negative controls are shown in this western blot. Molecular weights (kDa) are indicated at the left and right margins. B, Each subject's anti-IgE IgG value is presented in the bar graph. The 75th percentile (8.991 ng/mL) is represented by the dotted line. C, Median values, 25th and 75th percentiles are presented by Box-Whisker plots. Journal of Allergy and Clinical Immunology 2016 138, 893-895.e5DOI: (10.1016/j.jaci.2016.03.040) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions