The functional and structural basis of phospholipid recognition by the PG90 TCR. The functional and structural basis of phospholipid recognition by the.

Slides:

Advertisements

Similar presentations

CsEN components reveal precisely timed cellular programs that characterize the dynamic changes of the peripheral immune system over the course of pregnancy.

Advertisements

Pentamer–8I21 Fab and Pentamer–9I6 Fab interactions and structural superpositions. Pentamer–8I21 Fab and Pentamer–9I6 Fab interactions and structural superpositions.

Binding of Pentamer to cells.

Comparison of ternary TCR-lipid-CD1 complex structures.

Crystal structure of HCMV Pentamer.

Analysis of Pentamer interfaces.

Docking footprint of PG90 TCR on CD1b-PG.

TCRs bind to CD1b-PG complexes formed in cells.

Comparison of ternary TCR-lipid-CD1 complex structures.

Fig. 5 Metafluorophores with different photostability.

Fig. 2 2D-IR spectroscopy on liquid ZnPa under dry conditions.

Crystal structures of RSV G-antibody complexes.

Fig. 3 Aβ16–22 can interact with Aβ40 monomers and dimers.

Unique Fc functional profiling of HIV-specific Abs from neutralizers.

Fig. 1 Evolution of magnetic field lines around a foreshock bubble in the GSE-XY plane (z = 0): Results of a hybrid simulation. Evolution of magnetic field.

Fig. 6 Covalent inhibition of tuberculosis target MptpB.

Fig. 1 NP-free Ch-CNC droplets.

Fig. 3 Electron PSD in various regions.

Fig. 4 Complete separation of water and solute after stable and efficient solar evaporation. Complete separation of water and solute after stable and efficient.

Sequence conservation within antigenic sites γ1 and γ2, atomic interactions within the RSV G CCD, and model of RSV G glycoprotein. Sequence conservation.

Fig. 6 Comparison of properties of water models.

Ligands eluted from hpMR1+EC and hpMR1+MS contain both shared and unique ions. Ligands eluted from hpMR1+EC and hpMR1+MS contain both shared and unique.

MR1T clones with distinct TCR usage display differential recognition of discrete activating ligands. MR1T clones with distinct TCR usage display differential.

Fig. 2 Cryo-EM structure of Elp123 bound to tRNAAlaUGC.

Fig. 4 Structural details of tRNA binding to Elp123.

MR1Ts are recognized by hpMR1 tetramers loaded with a heterogeneous mixture of microbially derived ligands. MR1Ts are recognized by hpMR1 tetramers loaded.

Fig. 1 Study area and field site setting.

Fig. 1 Cryo-EM structure of yeast Elp123 showing its active site.

Destabilization of the WAIS in the unperturbed reference simulation

Fig. 2 Time series of ice loss from the Amundsen Sea sector for the cases of unperturbed destabilization (black) and mass deposition (colored). Time series.

Fig. 1 Bioinspired design of AAD for promoting wound contraction.

CsEN components reveal precisely timed cellular programs that characterize the dynamic changes of the peripheral immune system over the course of pregnancy.

Fig. 3 Forward model. Forward model. Summary of the resampled Monte Carlo simulations shown as histograms for epoch 1 (red), epoch 2 (green), and epoch.

Fig. 3 Photon number statistics resulting from Fock state |l, S − l〉 interference. Photon number statistics resulting from Fock state |l, S − l〉 interference.

Fig. 1 The illustration of discontinuous hydrogen bonding chains in FJU-23-H2O. The illustration of discontinuous hydrogen bonding chains in FJU-23-H2O.

Fig. 3 ET dynamics on the control and treatment watersheds during the pretreatment and treatment periods. ET dynamics on the control and treatment watersheds.

Fig. 2 Assignment of back-exchanged deuterated NaK2K.

Fig. 2 Cardiolipin binding sites in complex I.

Fig. 1 Boronic acid–rich dendrimer with robust efficiency in cytosolic protein delivery. Boronic acid–rich dendrimer with robust efficiency in cytosolic.

Fig. 1 Cross-sectional images of He-implanted V/Cu/V samples.

Fig. 4 Evolution of fraction of sickled RBCs under hypoxia.

Specificity profiling, activity in human plasma, and x-ray structure

Fig. 2 Schematic drawings of Göbekli Tepe skulls.

Fig. 1 Deficient CD73 and CD39 expressions and extracellular adenosine concentration in BM of OVX animals. Deficient CD73 and CD39 expressions and extracellular.

Fig. 1 OVA-releasing scaffolds concentrate OVA-specific CD4+T cells following ischemic injury. OVA-releasing scaffolds concentrate OVA-specific CD4+T cells.

Fig. 1 Empirical probability density functions of the estimated climatic drivers. Empirical probability density functions of the estimated climatic drivers.

Fig. 4 Relationships between light and economic parameters.

Fig. 4 Reactive MD simulation showing the origins of chemical and physical effects on friction. Reactive MD simulation showing the origins of chemical.

Fig. 5 Comparison of the liquid products generated from photocatalytic CO2 reduction reactions (CO2RR) and CO reduction reactions (CORR) on two catalysts.

Overall structure of AxqNOR and interhelical dimer interactions

Fig. 1 Observed postseismic DRs after the Tohoku earthquake through the repeated GPS-A observations. Observed postseismic DRs after the Tohoku earthquake.

Fig. 1 Location of the Jirzankal Cemetery.

MD simulation on the nonfouling mechanism of PTMAO at molecular level

Fig. 4 CO2 emission changes triggered by the JJJ clean air policy.

Fig. 5 Potential-energy energy profiles of 1-HAQ.

Fig. 3 Trackway TW1 under different lighting directions.

Fig. 3 Maximal energy intake.

Fig. 2 Comparison of the observed DRs and the estimates by the VR model and FL. Comparison of the observed DRs and the estimates by the VR model and FL.

Fig. 2 RVFV causes pathology within the liver, uterus, and placenta of pregnant dams. RVFV causes pathology within the liver, uterus, and placenta of pregnant.

Fig. 4 Spatial mapping of the distribution and intensity of industrial fishing catch. Spatial mapping of the distribution and intensity of industrial fishing.

Fig. 1 Example of diversified propagation patterns of the MJO.

Fig. 4 Effect of ionic content of LC medium.

Fig. 3 Interference of quantum clocks.

Fig. 4 Scaling laws distinguish biochemical networks from random networks across levels of organization. Scaling laws distinguish biochemical networks.

Fig. 2 Spatial distribution of five city groups.

Fig. 2 Daily TNC pickups and drop-offs for an average Wednesday in fall 2016 (1). Daily TNC pickups and drop-offs for an average Wednesday in fall 2016.

Fig. 4 Evolution of rate constants over varying interaction strengths.

Fig. 6 Schematic illustration of the decreased conformational stability in the N92I mutant and its activation mechanism. Schematic illustration of the.

Fig. 4 Orthosteric ligand-binding pocket in CysLT1R.

Fig. 3 Spatial distribution of the shoot density (high densities are represented in dark green and low ones in bright yellow) in a simulation of a P. oceanica.

Presentation transcript:

The functional and structural basis of phospholipid recognition by the PG90 TCR. The functional and structural basis of phospholipid recognition by the PG90 TCR. (A) Staining of the PG90 cell line by CD1b tetramers with a single alanine mutant at the indicated site with or without bound PG. Residues interacting with the PG90 TCR are highlighted in blue. MFI, mean fluorescence intensity. (B) Color coding summary: white, not tested; dark gray, no effect (<25% reduction); orange, moderate effect (25 to 75% reduction); red, markedly reduced binding (>75% reduction). (C) Electrostatic potential of the cationic cup. The potential contours are shown on a scale from +10.0 (positive charge, blue) to −10.0 kBT e−1 (negative charge, red); white indicates a value close to 0 kBT e−1 (neutral charge). (D) Side view of hydrogen bond network between PG (green) and PG90 TCR, with CDR1α, CDR3α, and CDR3β loops represented in teal, purple, and yellow, respectively. Contacts with the head group of PG (E) and GMM (F). The interactions are represented as red dashes, whereas the cyan dash represents the hydrogen bond (E), and salt bridge (F), that forms the arginine capstone. Adam Shahine et al. Sci. Immunol. 2017;2:eaao1384 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).