YAP/TAZ at the Roots of Cancer

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YAP/TAZ at the Roots of Cancer Francesca Zanconato, Michelangelo Cordenonsi, Stefano Piccolo Cancer Cell Volume 29, Issue 6, Pages 783-803 (June 2016) DOI: 10.1016/j.ccell.2016.05.005 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Schematic Overview of YAP/TAZ Functions in Cancer Cells See text for details. Cancer Cell 2016 29, 783-803DOI: (10.1016/j.ccell.2016.05.005) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 2 YAP/TAZ in Human Tumors Tumor types for which epidemiological data and functional evidence of YAP/TAZ activation have been reported. Cancer Cell 2016 29, 783-803DOI: (10.1016/j.ccell.2016.05.005) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 3 Inputs Regulating YAP/TAZ Activity in Cancer Cells See text for details. Cancer Cell 2016 29, 783-803DOI: (10.1016/j.ccell.2016.05.005) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 4 The Onset of Drug Resistance Is Accompanied by YAP/TAZ Activation (A–C) Drug-sensitive cancer cells (A). The mechanism of YAP/TAZ activation in response to molecularly targeted therapies involves cell-autonomous events (B), such as cytoskeletal rearrangements leading to increased mechanosensitivity, as well as cell extrinsic events (C), such as remodeling of the extracellular microenvironment. Possibly, these two mechanisms cooperate to induce YAP/TAZ nuclear accumulation in cancer cells, leading to uncontrolled cell survival and proliferation in spite of drug administration. Cancer Cell 2016 29, 783-803DOI: (10.1016/j.ccell.2016.05.005) Copyright © 2016 Elsevier Inc. Terms and Conditions