Ying-Ying Dong, MD, Min Wu, MD, Anthony P. C

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Presentation transcript:

Effect of Hypoxia-Reoxygenation on Endothelial Function in Porcine Cardiac Microveins Ying-Ying Dong, MD, Min Wu, MD, Anthony P.C. Yim, MD, Guo-Wei He, MD, PhD The Annals of Thoracic Surgery Volume 81, Issue 5, Pages 1708-1714 (May 2006) DOI: 10.1016/j.athoracsur.2005.12.002 Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Partial pressure of oxygen (Po2) in hypoxia. Data are shown as mean ± standard error of the mean. The Annals of Thoracic Surgery 2006 81, 1708-1714DOI: (10.1016/j.athoracsur.2005.12.002) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Concentration-relaxation curves for bradykinin in the U46619 (100 nM) precontracted cardiac veins before (open circles) and after (control; solid circles) 90-minute incubation in Krebs solution in the presence of indomethacin (7 μM), NG-nitro-L-arginine (300 μM), and oxyhemoglobin (20 μM). Data are shown as mean ± standard error of the mean (n = 8; p = 0.4; 2-way analysis of variance). The Annals of Thoracic Surgery 2006 81, 1708-1714DOI: (10.1016/j.athoracsur.2005.12.002) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Concentration-relaxation curves for bradykinin in the U46619 (100 nM) precontracted cardiac veins (see Material and Methods) with the presence of indomethacin (7 μM), NG-nitro-L-arginine (300 μM), and oxyhemoglobin (20 μM); (A) (group IA) before (control; solid circles) and after (H-R; open circles) 30-minute hypoxia followed by 30-minute reoxygenation in Krebs solution at 37°C; or (B) (group IB) before (control; solid circles) and after (H/R; open circles) 60-minute hypoxia followed by 30-minute reoxygenation in Krebs solution at 37°C. Data are shown as mean ± standard error of the mean. **p less than 0.01 compared with the control (n = 8, 2-way analysis of variance); #p less than 0.01 compared with H/R (30/30) in (A). (H/R = hypoxia reoxygenation.) The Annals of Thoracic Surgery 2006 81, 1708-1714DOI: (10.1016/j.athoracsur.2005.12.002) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Concentration-relaxation curves for bradykinin in the U46619 (100 nM) precontracted microveins (see Material and Methods) with the presence of indomethacin (7 μM), NG-nitro-L-arginine (300 μM), and oxyhemoglobin (20 μM); (A) (group IIA) before (control; solid circles) and after (H/R; open circles) 60-minute hypoxia followed by 30-minute reoxygenation in ST at 37°C; or (B) (group IIB) 60-minute hypoxia followed by 30-minute reoxygenation in Krebs (H/R; solid circles) or in ST (H/R; open circles) at 4°C. Data are shown as mean ± standard error of the mean. **p less than 0.01 compared with the control (n = 8, 2-way analysis of variance). (H/R = hypoxia reoxygenation; ST = St. Thomas solution.) The Annals of Thoracic Surgery 2006 81, 1708-1714DOI: (10.1016/j.athoracsur.2005.12.002) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions