Identification of a Genetic Locus for Ichthyosis Vulgaris on Chromosome 10q22.3– q24.2 Ping Liu, Qingyu Yang, Xu Wang, Aiping Feng, Tao Yang, Rong Yang,

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Identification of a Genetic Locus for Ichthyosis Vulgaris on Chromosome 10q22.3– q24.2 Ping Liu, Qingyu Yang, Xu Wang, Aiping Feng, Tao Yang, Rong Yang, Pengyun Wang, Mingxiong Yuang, Mugen Liu, Jing Yu Liu, Qing K. Wang Journal of Investigative Dermatology Volume 128, Issue 6, Pages 1418-1422 (July 2008) DOI: 10.1038/sj.jid.5701191 Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Typical clinical features of IV in Chinese family 1. Note the marked, fine, white flaky scaling on the exterior surface of the dorsum of the pretibial regions. Journal of Investigative Dermatology 2008 128, 1418-1422DOI: (10.1038/sj.jid.5701191) Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Exclusion of linkage to the FLG gene on chromosome 1q in two Chinese families with IV. (a) The pedigree structure for family 1 and genotyping results for four markers on chromosome 1q22. Affected individuals are shown as filled squares (males) or circles (females), and normal individuals are indicated with open symbols. Deceased individuals are marked with slashes (/). The proband is indicated by an arrow. Haplotypes are shown with vertical bars, disease-linked haplotype with filled bars, and normal haplotypes with open bars. Positions for recombinations are marked with arrowheads. (b) The pedigree structure for family 2, and linkage and haplotype analyses in the family. (c) Ideogram of chromosome 1 showing the position and distance of FLG to its flanking markers. Journal of Investigative Dermatology 2008 128, 1418-1422DOI: (10.1038/sj.jid.5701191) Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Identification of a new genetic locus for IV with markers on chromosome 10q22.3–q24.2. (a) Linkage and haplotype analyses in family 1. (b) Linkage and haplotype analyses in family 2. (c) Ideogram of chromosome 10 showing Giemsa banding patterns and the detailed location of the new genetic locus for IV. Journal of Investigative Dermatology 2008 128, 1418-1422DOI: (10.1038/sj.jid.5701191) Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions