Keeping in Touch to Differentiate

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Presentation transcript:

Keeping in Touch to Differentiate Chii J. Chan, Takashi Hiiragi Developmental Cell Volume 43, Issue 2, Pages 113-114 (October 2017) DOI: 10.1016/j.devcel.2017.10.006 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Positive Feedback between Cell-Cell Contact Duration and Nodal Signaling Leads to Cell Fate Bifurcation during Zebrafish Gastrulation (A) Schematic representation of the lateral view of a 60% epiboly zebrafish embryo. Ppl progenitor cells will differentiate into the ppl and endoderm cells. (B) Multi-scale modeling incorporating in vitro and in vivo studies of cell-cell contact dynamics and gene regulatory network explains the observed correlation between gsc expression levels and contact dynamics in vivo. (C) Delay in Nodal signaling gives rise to deterministic bistability from the positive feedback mechanism, which corresponds to the segregation of cells into ppl and endoderm populations. Developmental Cell 2017 43, 113-114DOI: (10.1016/j.devcel.2017.10.006) Copyright © 2017 Elsevier Inc. Terms and Conditions