POINT: Will New Anti-eosinophilic Drugs Be Useful in Asthma Management

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POINT: Will New Anti-eosinophilic Drugs Be Useful in Asthma Management POINT: Will New Anti-eosinophilic Drugs Be Useful in Asthma Management? Yes Paul M. O'Byrne, MBBCh, FCCP CHEST Volume 151, Issue 1, Pages 14-17 (January 2017) DOI: 10.1016/j.chest.2016.09.021 Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 1 A, Number of asthma exacerbations in patients receiving either IV or subcutaneous mepolizumab or placebo. The rate of exacerbations was reduced by 47% (95% CI, 28-60) among patients receiving IV mepolizumab and by 53% (95% CI, 36-65) among those receiving subcutaneous mepolizumab, compared with those receiving placebo (P < .001 for both comparisons). B, Mean FEV1 as a percentage of the predicted value. At week 32, there was greater improvement from baseline in the two mepolizumab groups than in the placebo group—a 100-mL greater increase in the IV mepolizumab group than in the placebo group (P = .02) and a 98-mL greater increase in the subcutaneous mepolizumab group than in the placebo group (P = .03). The bars indicate 95% CIs. (Reprinted with permission from Ortega et al.13) CHEST 2017 151, 14-17DOI: (10.1016/j.chest.2016.09.021) Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 2 The effect of the anti-IL-4Rα monoclonal antibody dupilumab on severe exacerbation event rates estimated from the 24-week treatment period in the overall population. Error bars indicate point estimate from adjusted annualized severe exacerbation event rates in the 24-week treatment period. (P < .01; P < .001; P < .05 vs placebo. (Reprinted with permission from Wenzel et al.20) CHEST 2017 151, 14-17DOI: (10.1016/j.chest.2016.09.021) Copyright © 2016 American College of Chest Physicians Terms and Conditions