Basic fibroblast growth factor may improve devascularized sternal healing Atsushi Iwakura, MD, Yasuhiko Tabata, PhD, Kazunobu Nishimura, MD, Tatsuo Nakamura,

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Presentation transcript:

Basic fibroblast growth factor may improve devascularized sternal healing Atsushi Iwakura, MD, Yasuhiko Tabata, PhD, Kazunobu Nishimura, MD, Tatsuo Nakamura, MD, Yasuhiko Shimizu, MD, Masatoshi Fujita, MD, Masashi Komeda, MD The Annals of Thoracic Surgery Volume 70, Issue 3, Pages 824-828 (September 2000) DOI: 10.1016/S0003-4975(00)01645-3

Fig 1 The peristernal blood flow was measured by means of a noncontact laser Doppler flowmeter after removal of the bilateral internal thoracic arteries (BITA) and 4 weeks after surgical treatment as follows: In group A, a gelatin sheet containing 100 μg of basic fibroblast growth factor was applied after removal of the bilateral internal thoracic arteries (BITA). In group B, the BITA were removed, but no gelatin sheet was applied. In group C, the BITA were left intact.. The Annals of Thoracic Surgery 2000 70, 824-828DOI: (10.1016/S0003-4975(00)01645-3)

Fig 2 Micrographs (hematoxylin-eosin stained, 20 × magnification) showing new vessels in the connective tissue around the sternum after surgical treatment in three study groups. (A) A gelatin sheet containing 100 μg of basic fibroblast growth factor was applied after removal of the bilateral internal thoracic arteries (BITA). (B) The BITA were removed, but no gelatin sheet was applied. (C)The BITA were left intact. The Annals of Thoracic Surgery 2000 70, 824-828DOI: (10.1016/S0003-4975(00)01645-3)

Fig 3 Histologic cross-sections of regenerated sternum were obtained 4 weeks after surgical treatment as follows: (A) A gelatin sheet containing 100 μg of basic fibroblast growth factor was applied after removal of the bilateral internal thoracic arteries (BITA). (B) The BITA were removed, but no gelatin sheet was applied. (C)The BITA were left intact. The Annals of Thoracic Surgery 2000 70, 824-828DOI: (10.1016/S0003-4975(00)01645-3)

Fig 4 The bone mineral content and density was assessed by dual energy roentgenogram absorptometry after surgical treatment. In group A, a gelatin sheet containing 100 μg of basic fibroblast growth factor was applied after removal of the bilateral internal thoracic arteries (BITA). In group B, the BITA were removed, but no gelatin sheet was applied. In group C, the BITA were left intact. The Annals of Thoracic Surgery 2000 70, 824-828DOI: (10.1016/S0003-4975(00)01645-3)

Fig 5 The osteoclast index was calculated as the number of osteoclast/sternum perimeter in mm after surgical treatment. In group A, a gelatin sheet containing 100 μg of basic fibroblast growth factor was applied after removal of the bilateral internal thoracic arteries (BITA). In group B, the BITA were removed, but no gelatin sheet was applied. In group C, the BITA were left intact. The Annals of Thoracic Surgery 2000 70, 824-828DOI: (10.1016/S0003-4975(00)01645-3)