Clemens Esche, Vladimir M

Slides:

Advertisements

Similar presentations

Ultraviolet B-Induced Skin Angiogenesis Is Associated with a Switch in the Balance of Vascular Endothelial Growth Factor and Thrombospondin-1 Expression

Advertisements

Unprocessed Interleukin-36α Regulates Psoriasis-Like Skin Inflammation in Cooperation With Interleukin-1 Katelynn A. Milora, Hangfei Fu, Ornella Dubaz,

EpCAM Expressed by Murine Epidermal Langerhans Cells Modulates Immunization to an Epicutaneously Applied Protein Antigen Takeshi Ouchi, Gaku Nakato,

Type I IL-1 Receptor Mediates IL-1 and Intracellular IL-1 Receptor Antagonist Effects in Skin Inflammation Gaby Palmer, Dominique Talabot-Ayer, Gürkan.

Inhibition of UVB-Induced Skin Tumor Development by Drinking Green Tea Polyphenols Is Mediated Through DNA Repair and Subsequent Inhibition of Inflammation

Induction of Autoimmunity in a Bleomycin-Induced Murine Model of Experimental Systemic Sclerosis: An Important Role for CD4+ T Cells Hideaki Ishikawa,

Targeted Overexpression of the Angiogenesis Inhibitor Thrombospondin-1 in the Epidermis of Transgenic Mice Prevents Ultraviolet-B-Induced Angiogenesis.

Oral Administration of Poly-γ-Glutamate Ameliorates Atopic Dermatitis in Nc/Nga Mice by Suppressing Th2-Biased Immune Response and Production of IL-17A

Molecular Regulation of UVB-Induced Cutaneous Angiogenesis

Liver X Receptor Activators Display Anti-Inflammatory Activity in Irritant and Allergic Contact Dermatitis Models: Liver-X-Receptor-Specific Inhibition.

Vγ4 γδ T Cells Provide an Early Source of IL-17A and Accelerate Skin Graft Rejection Yashu Li, Zhenggen Huang, Rongshuai Yan, Meixi Liu, Yang Bai, Guangping.

IL-27 Activates Th1-Mediated Responses in Imiquimod-Induced Psoriasis-Like Skin Lesions Sayaka Shibata, Yayoi Tada, Yoshihide Asano, Koichi Yanaba, Makoto.

Estrogen Receptor α, but not Estrogen Receptor β, is Involved in the Regulation of the Hair Follicle Cycling as well as the Thickness of Epidermis in.

Topical Peroxisome Proliferator Activated Receptor-α Activators Reduce Inflammation in Irritant and Allergic Contact Dermatitis Models1 Mary Y. Sheu,

IL-23 from Langerhans Cells Is Required for the Development of Imiquimod-Induced Psoriasis-Like Dermatitis by Induction of IL-17A-Producing γδ T Cells

The Aryl Hydrocarbon Receptor Is Involved in UVR-Induced Immunosuppression Fatemeh Navid, Anika Bruhs, Winfried Schuller, Ellen Fritsche, Jean Krutmann,

Sandra Holzmann, BSc, Christoph H

Caspase-14-Deficient Mice Are More Prone to the Development of Parakeratosis Esther Hoste, Geertrui Denecker, Barbara Gilbert, Filip Van Nieuwerburgh,

Raija Tammi Journal of Investigative Dermatology

Enhanced Cutaneous Inflammatory Reactions to Aspergillus fumigatus in a Murine Model of Chronic Granulomatous Disease Jeffrey E. Petersen Journal of.

The Spatial and Temporal Expression Patterns of Integrin α9β1 and One of Its Ligands, the EIIIA Segment of Fibronectin, in Cutaneous Wound Healing Purva.

Gene Correction Reduces Cutaneous Inflammation and Granuloma Formation in Murine X-Linked Chronic Granulomatous Disease W. Scott Goebel, Lawrence A.

Toll-Like Receptor 3 Increases Allergic and Irritant Contact Dermatitis Naomi Nakamura, Risa Tamagawa-Mineoka, Mayumi Ueta, Shigeru Kinoshita, Norito.

IL-18, but Not IL-12, Induces Production of IFN-γ in the Immunosuppressive Environment of HPV16 E7 Transgenic Hyperplastic Skin Christina Gosmann, Ian.

Interleukin-1β But Not Tumor Necrosis Factor is Involved in West Nile Virus-Induced Langerhans Cell Migration from the Skin in C57BL/6 Mice Scott N.

Toshiyuki Yamamoto, Kiyoshi Nishioka

Stimulation of PPARα Promotes Epidermal Keratinocyte Differentiation In Vivo László G. Kömüves, Karen Hanley, Anne-Marie Lefebvre, Mao-Qiang Man, Dean.

Effective Narrow-Band UVB Radiation Therapy Suppresses the IL-23/IL-17 Axis in Normalized Psoriasis Plaques Leanne M. Johnson-Huang, Mayte Suárez-Fariñas,

Cutaneous Denervation of Psoriasiform Mouse Skin Improves Acanthosis and Inflammation in a Sensory Neuropeptide-Dependent Manner Stephen M. Ostrowski,

CD24a Expression Levels Discriminate Langerhans Cells from Dermal Dendritic Cells in Murine Skin and Lymph Nodes Susanne Stutte, Bettina Jux, Charlotte.

Interleukin-18 and the Costimulatory Molecule B7-1 Have a Synergistic Anti-Tumor Effect on Murine Melanoma; Implication of Combined Immunotherapy for.

Epidermal Langerhans Cells Rapidly Capture and Present Antigens from C-Type Lectin- Targeting Antibodies Deposited in the Dermis Vincent Flacher, Christoph.

Liver X Receptor Activators Display Anti-Inflammatory Activity in Irritant and Allergic Contact Dermatitis Models: Liver-X-Receptor-Specific Inhibition.

Minutes of the Board of Directors Meeting

Distinct Roles for Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Controlling the Rate of Hair Follicle Morphogenesis Natalia V. Botchkareva,

Resistance to Alopecia Areata in C3H/HeJ Mice Is Associated with Increased Expression of Regulatory Cytokines and a Failure to Recruit CD4+ and CD8+ Cells

Botulinum Neurotoxin A Decreases Infiltrating Cutaneous Lymphocytes and Improves Acanthosis in the KC-Tie2 Mouse Model Nicole L. Ward, Kevin D. Kavlick,

Vladimir A. Botchkarev, Natalia V. Botchkareva, Kathryn M

Manabu Taniguchi, Shinsuke Matsuzaki, Masaya Tohyama

Endothelins are Involved in Regulating the Proliferation and Differentiation of Mouse Epidermal Melanocytes in Serum-Free Primary Culture Tomohisa Hirobe

Rebecca M. Porter, Julia Reichelt, Declan P. Lunny, Thomas M. Magin, E

Attenuation of UVB-Induced Sunburn Reaction and Oxidative DNA Damage with no Alterations in UVB-Induced Skin Carcinogenesis in Nrf2 Gene-Deficient Mice

Engagement of CD47 Inhibits the Contact Hypersensitivity Response Via the Suppression of Motility and B7 Expression by Langerhans Cells Xijun Yu, Atsushi.

Michael C. Velarde Journal of Investigative Dermatology

Yoshiharu Kawaguchi Journal of Investigative Dermatology

Syed M. Meeran, Thejass Punathil, Santosh K. Katiyar

Ultraviolet B-Induced Skin Angiogenesis Is Associated with a Switch in the Balance of Vascular Endothelial Growth Factor and Thrombospondin-1 Expression

1,25-Dihydroxyvitamin D Exerts Similar Immunosuppressive Effects as UVR but Is Dispensable for Local UVR-Induced Immunosuppression Agatha Schwarz, Fatemeh.

Epidermal CCL27 Expression Is Regulated during Skin Development and Keratinocyte Differentiation Michael Mildner, Marion Prior, Maria Gschwandtner, Christopher.

Hirotake Suzuki, Binghe Wang, Gulnar M

Sandra Holzmann, BSc, Christoph H

Linda J. Johnston, Nicholas J.C. King

Society for Investigative Dermatology 2010 Meeting Minutes

Oral Administration of Poly-γ-Glutamate Ameliorates Atopic Dermatitis in Nc/Nga Mice by Suppressing Th2-Biased Immune Response and Production of IL-17A

Distinct Roles for Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Controlling the Rate of Hair Follicle Morphogenesis Natalia V. Botchkareva,

Research Snippets Journal of Investigative Dermatology

Elimination of CD4+ T Cells Enhances Anti-Tumor Effect of Locally Secreted Interleukin- 12 on B16 Mouse Melanoma and Induces Vitiligo-Like Coat Color Alteration

Expression of Mast Cell Growth Modulating and Chemotactic Factors and their Receptors in Human Cutaneous Scars Barbara Hermes Journal of Investigative.

Research Snippets from the British Journal of Dermatology

Gene Correction Reduces Cutaneous Inflammation and Granuloma Formation in Murine X-Linked Chronic Granulomatous Disease W. Scott Goebel, Lawrence A.

Journal of Investigative Dermatology

Systemic PPARγ Ligation Inhibits Allergic Immune Response in the Skin

An Important Role of Lymphatic Vessels in the Control of UVB-Induced Edema Formation and Inflammation Kentaro Kajiya, Michael Detmar Journal of Investigative.

Marta E. Polak, Louise Newell, Vadim Y

Journal of Investigative Dermatology

Keratinocyte-Derived Granulocyte-Macrophage Colony Stimulating Factor Accelerates Wound Healing: Stimulation of Keratinocyte Proliferation, Granulation.

Interleukin-10-Treated Dendritic Cells Modulate Immune Responses of Naive and Sensitized T Cells In Vivo Gabriele Müller, Anke Müller Journal of Investigative.

Errata Journal of Investigative Dermatology

The Interleukin-6 Cytokine System Regulates Epidermal Permeability Barrier Homeostasis Xu-Ping Wang, Michael Schunck, Karl-Josef Kallen, Claudia Neumann,

Delayed Wound Healing in CXCR2 Knockout Mice

Presentation transcript:

Differential Regulation of Epidermal and Dermal Dendritic Cells by IL-12 and Flt3 Ligand Clemens Esche, Vladimir M. Subbotin, Oriana Hunter, Jean-Marie Peron, Charles Maliszewski, Michael T. Lotze, Michael R. Shurin Journal of Investigative Dermatology Volume 113, Issue 6, Pages 1028-1032 (December 1999) DOI: 10.1046/j.1523-1747.1999.00779.x Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 FL and IL-12 differentially regulate DC in murine epidermis and dermis. C57BL/6 mice were injected i.p. with 10 μg FL, or 1 μg IL-12, both together, or 0.01% mouse serum albumin for 10 consecutive days. Animals were sacrificed 24 h after the last injection. Histograms represent the number of DC per mm2 (y-axis) in epidermis (solid bars) and dermis (stippled bars) in control mice and after cytokine treatment (x-axis). Upper panel: NLDC-145+ cells in wild-type (a) and IL-12 knockout mice (b). Lower panel: CD86+ cells in wild-type (c) and IL-12 knockout mice (d). The means ± SEM from three separate experiments are shown. *p < 0.05 compared with the control by one-way ANOVA. Journal of Investigative Dermatology 1999 113, 1028-1032DOI: (10.1046/j.1523-1747.1999.00779.x) Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Effect of FL treatment on the expression of NLDC-145 and CD86 in wild-type mice. (a, b) NLDC-145; (c, d) CD86. Immunohistochemistry shown is representative of three independent experiments. (a) Control, (b) FL treatment. FL treatment resulted in a significant accumulation of both NLDC-145+ cells (b) and CD86+ cells (d) preferentially in the dermis compared with the control specimens (a, c). Scale bar: 110 μm. Journal of Investigative Dermatology 1999 113, 1028-1032DOI: (10.1046/j.1523-1747.1999.00779.x) Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 IL-12 significantly decreased and FL slightly increased the epidermal thickness. Histogram showing the epidermal thickness in μm (y-axis) in different treatment groups (x-axis). Solid bars represent the data from wild-type mice and stippled bars represent the data from IL-12 knockout mice. Histograms show the means (± SEM) based on three independent experiments. *p < 0.05 vs control by one-way ANOVA. Journal of Investigative Dermatology 1999 113, 1028-1032DOI: (10.1046/j.1523-1747.1999.00779.x) Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 FL and IL-12 reciprocally change epidermal cellularity. Histogram showing epidermal cellularity in cells per mm2 (y-axis) in different treatment groups (x-axis). Solid bars represent the data from wild-type mice and stippled bars represent the data from IL-12 knockout mice. In wild-type mice, FL administration induced an increase in epidermal cell numbers whereas IL-12 induced a decrease. In IL-12 knockout mice, we observed the opposite effect. Histograms show the means ± SEM based on three independent experiments. *p < 0.05 vs control by one-way ANOVA. Journal of Investigative Dermatology 1999 113, 1028-1032DOI: (10.1046/j.1523-1747.1999.00779.x) Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 5 FL induces an increase in dermal cellularity. Histogram showing dermal cellularity in cells per mm2 (y-axis) in different treatment groups (x-axis). Solid bars represent the data from wild-type mice and stippled bars represent the data from IL-12 knockout mice. Histograms show the mean (±SEM) based on three independent experiments. *p < 0.05 vs control by one-way ANOVA. Journal of Investigative Dermatology 1999 113, 1028-1032DOI: (10.1046/j.1523-1747.1999.00779.x) Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions