5-ALA increased porphyrin production, which was further enhanced by vitamin B12 supplementation in acne-associated type IA-2 strains. 5-ALA increased porphyrin.

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5-ALA increased porphyrin production, which was further enhanced by vitamin B12 supplementation in acne-associated type IA-2 strains. 5-ALA increased porphyrin production, which was further enhanced by vitamin B12 supplementation in acne-associated type IA-2 strains. P. acnes strains were cultured in medium with substrate 5-ALA (0.1 mg/ml) (grey bars) or without 5-ALA (white bars) or with both 5-ALA and vitamin B12 (10 µg/ml) added (black bars). 5-ALA significantly increased porphyrin production in acne-associated type IA-2 strains (P < 0.0001) and in health-associated type II strains (P ≤ 0.06, except for HL001PA1). Vitamin B12 supplementation further increased porphyrin production in the presence of 5-ALA in acne-associated type IA-2 strains, but not in health-associated type II strains. Each bar represents the porphyrins produced by each strain normalized to the bacterial culture density. The means plus standard errors (error bars) of data obtained from at least three independent experiments with at least three replicates each are shown. Tremylla Johnson et al. mSphere 2016; doi:10.1128/mSphere.00023-15