Integrating real-life studies in the global therapeutic research framework  Nicolas Roche, Helen K Reddel, Alvar Agusti, Eric D Bateman, Jerry A Krishnan,

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Integrating real-life studies in the global therapeutic research framework  Nicolas Roche, Helen K Reddel, Alvar Agusti, Eric D Bateman, Jerry A Krishnan, Richard J Martin, Alberto Papi, Dirkje Postma, Mike Thomas, Guy Brusselle, Elliot Israel, Cynthia Rand, Alison Chisholm, David Price  The Lancet Respiratory Medicine  Volume 1, Issue 10, Pages e29-e30 (December 2013) DOI: 10.1016/S2213-2600(13)70199-1 Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 1 A conceptual framework for therapeutic research Studies are described in terms of their design or ecology of care (x-axis) and their population characteristics (y-axis), with each axis representing a continuum. RCT=randomised controlled trial. The Lancet Respiratory Medicine 2013 1, e29-e30DOI: (10.1016/S2213-2600(13)70199-1) Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 2 An illustration of how the conceptual framework could be applied to a specific condition (asthma)3–9 AHR=airway hyper-responsiveness. BD rev=post-bronchodilator reversibility. RCT=randomised controlled trial. The Lancet Respiratory Medicine 2013 1, e29-e30DOI: (10.1016/S2213-2600(13)70199-1) Copyright © 2013 Elsevier Ltd Terms and Conditions

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