Volume 150, Issue 1, Pages 145-155.e4 (January 2016) Hepatitis C Virus Infection Is Associated With Increased Cardiovascular Mortality: A Meta-Analysis of Observational Studies  Salvatore Petta, Marcello Maida, Fabio Salvatore Macaluso, Marco Barbara, Anna Licata, Antonio Craxì, Calogero Cammà  Gastroenterology  Volume 150, Issue 1, Pages 145-155.e4 (January 2016) DOI: 10.1053/j.gastro.2015.09.007 Copyright © 2016 AGA Institute Terms and Conditions

Figure 1 Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram of the search process. Gastroenterology 2016 150, 145-155.e4DOI: (10.1053/j.gastro.2015.09.007) Copyright © 2016 AGA Institute Terms and Conditions

Figure 2 Meta-analysis of 3 studies that assessed the impact of HCV infection on CVD-related mortality, using the random-effects model. ORs and 95% CIs are shown on a logarithm scale. Studies are arranged by publication year. Study names are provided in the corresponding references. Gastroenterology 2016 150, 145-155.e4DOI: (10.1053/j.gastro.2015.09.007) Copyright © 2016 AGA Institute Terms and Conditions

Figure 3 Meta-analysis of 9 studies that assessed the impact of HCV infection on the presence of carotid plaques, using the random-effects model. (A) Overall impact and (B) impact according to the prevalence of smoking habit in the population (<20% vs >20%). ORs and 95% CIs are shown on a logarithm scale. Studies are arranged by publication year. Study names are provided in the corresponding references. Gastroenterology 2016 150, 145-155.e4DOI: (10.1053/j.gastro.2015.09.007) Copyright © 2016 AGA Institute Terms and Conditions

Figure 4 Meta-analysis of 8 studies that assessed the impact of HCV infection on cerebrocardiovascular events. (A) Overall impact. Impact in subgroups according to (B) prevalence of diabetes, (C) prevalence of hypertension, (D) study design, and (E) age. ORs and 95% CIs are shown on a logarithm scale. Studies are arranged by publication year. Study names are provided in the corresponding references. Gastroenterology 2016 150, 145-155.e4DOI: (10.1053/j.gastro.2015.09.007) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 1 Meta-analysis of 7 studies that assessed the impact of HCV infection on IMT, using the random-effects model. ORs and 95% CIs are shown on a logarithm scale. Studies are arranged by publication year. Study names are provided in the corresponding references. Gastroenterology 2016 150, 145-155.e4DOI: (10.1053/j.gastro.2015.09.007) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 2 Meta-analysis of studies that assessed the impact of HCV infection on cardiovascular or cerebrovascular events, using the random-effects model. ORs and 95% CIs for the effect of HCV infection on (A) cardiovascular events or (B) cerebrovascular events are shown on a logarithm scale. Studies are arranged by publication year. Study names are provided in the corresponding references. Gastroenterology 2016 150, 145-155.e4DOI: (10.1053/j.gastro.2015.09.007) Copyright © 2016 AGA Institute Terms and Conditions