Y. Sun, N. Haines, A. Roberts, M. Ruffolo, D. Mauerhan, J. Ingram, M

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Presentation transcript:

Phosphocitrate reduced cartilage degeneration in non-calcification induced osteoarthritis Y. Sun, N. Haines, A. Roberts, M. Ruffolo, D. Mauerhan, J. Ingram, M. Cox, E. Hanley Osteoarthritis and Cartilage Volume 23, Pages A395-A396 (April 2015) DOI: 10.1016/j.joca.2015.02.730 Copyright © 2015 Terms and Conditions

Figure 1. Radiographs of the medial meniscus Figure 1. Radiographs of the medial meniscus. Left: Radiograph of medial meniscus of the left knee (non-operated knee) of the guinea pigs. The anterior horn was severely calcified or ossified (arrow). Right: Radiographs of medial meniscus of right knee (surgery performed knee) of the guinea pigs. The severely ossified anterior horn was absent, removing by the partial-meniscectomy surgery (arrow). Osteoarthritis and Cartilage 2015 23, A395-A396DOI: (10.1016/j.joca.2015.02.730) Copyright © 2015 Terms and Conditions

Figure 2. Mean histological scores of the tibia plateaus Figure 2. Mean histological scores of the tibia plateaus. Left bar group: Mean histological scores of the medial tibia plateaus of the rights knees in the untreated and PC-treated guinea pigs. Right bar group: Mean histological scores of the lateral tibia plateaus of the right knees in the untreated and PC-treated guinea pigs. * = P < 0.05 PC-treated versus the untreated guinea pigs. Osteoarthritis and Cartilage 2015 23, A395-A396DOI: (10.1016/j.joca.2015.02.730) Copyright © 2015 Terms and Conditions

Figure 3. Cartilage thickness Figure 3. Cartilage thickness. Left: thickness of the medial tibia cartilage in the untreated guinea pigs. Right: thickness of the medial tibia cartilage in the PC-treated guinea pigs. Osteoarthritis and Cartilage 2015 23, A395-A396DOI: (10.1016/j.joca.2015.02.730) Copyright © 2015 Terms and Conditions

Figure 4. Immunostaining scores. Left bar group: MMP-15 immunostaining Figure 4. Immunostaining scores. Left bar group: MMP-15 immunostaining. Middle bar group: ADAMTS5 immunostaining. Right bar group: CCL-5 immunostaining. Osteoarthritis and Cartilage 2015 23, A395-A396DOI: (10.1016/j.joca.2015.02.730) Copyright © 2015 Terms and Conditions