Volume 82, Issue 7, Pages (October 2012)

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Volume 82, Issue 7, Pages 729-730 (October 2012) Journal Club Kidney International Volume 82, Issue 7, Pages 729-730 (October 2012) DOI: 10.1038/ki.2012.323 Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure Relationships between clinical subtype and ANCA specificity in ANCA-associated vasculitis and associations of the MHC locus with proteinase 3 ANCA and myeloperoxidase ANCA. (a) Venn diagram shows the overlap between GPA or MPA and ANCA specificity (proteinase 3 (PR3) or myeloperoxidase (MPO)) in the combined cohort. (b) -Log10 P values for the association of single-nucleotide polymorphisms (SNPs) at the MHC locus in all ANCA-associated vasculitis patients. (c) PR3 ANCA only. (d) MPO ANCA only. The gray vertical line (b–d) indicates the genomic location of the most associated SNP. The arrow (d) indicates the position of rs5000634 (HLA-DQ). (e) The genomic architecture of the MHC locus shows the recombination rates along the sequence as well. Kidney International 2012 82, 729-730DOI: (10.1038/ki.2012.323) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure Survival plot demonstrates higher mortality in the high-dose FGF23 antibody (Ab) group. Started with normal + control Ab, normal diet (ND) (n = 10); sham-treated + control Ab, high-phosphate diet (HPD) (n = 12); 5/6Nx + control Ab, HPD (n = 16); 5/6Nx + FGF23 Ab (3 mg/kg), HPD (n = 16); 5/6Nx + FGF23 Ab (10 mg/kg), HPD (n = 16). Note that the normal + control Ab, ND, and sham-treated + control Ab groups’ results are superimposable at 100% survival throughout the 6-week treatment period. Kidney International 2012 82, 729-730DOI: (10.1038/ki.2012.323) Copyright © 2012 International Society of Nephrology Terms and Conditions